Encontrados 10 documentos, a visualizar página 1 de 1
Stimulation of Neural Stem Cell Proliferation by Inhibition of Phosphodiesterase 5
Santos, Ana I.; Carreira, Bruno P.; Nobre, Rui J.; Carvalho, Caetana M.; Araujo, Ines M.The involvement of nitric oxide (NO) and cyclic GMP (cGMP) in neurogenesis has been progressively unmasked over the last decade. Phosphodiesterase 5 (PDE5) specifically degrades cGMP and is highly abundant in the mammalian brain. Inhibition of cGMP hydrolysis by blocking PDE5 is a possible strategy to enhance the first step of neurogenesis, proliferation of neural stem cells (NSC). In this work, we have studied...
Evaluation of neurotoxic and neuroprotective pathways affected by antiepileptic...
Morte, Maria I.; Carreira, Bruno P.; Falcão, Maria J.; Ambrosio, António M.; Soares-da-Silva, Patrício; Araújo, Inês M.; Carvalho, Caetana M.In this study we evaluated the neurotoxicity of eslicarbazepine acetate (ESL), and of its in vivo metabolites eslicarbazepine (S-Lic) and R-licarbazepine (R-Lic), as compared to the structurally-related compounds carbamazepine (CBZ) and oxcarbazepine (OXC), in an in vitro model of cultured rat hippocampal neurons. The non-related antiepileptic drugs (AEDs) lamotrigine (LTG) and sodium valproate (VPA) were also ...
As tapeçarias de Pastrana: uma iconografia da guerra
Araújo, Inês Filipa MeiraTese de mestrado, Arte, Património e Teoria do Restauro, Universidade de Lisboa, Faculdade de Letras, 2013 ; As Tapeçarias de Pastrana formam um núcleo de quatro tapeçarias que representa a conquista das cidades marroquinas de Arzila, intituladas O desembarque em Arzila, O cerco a Arzila, O assalto a Arzila, e de Tânger, A entrada em Tânger, pelo rei português D. Afonso V. Estas mostram-se como uma das princip...
Clinical predictors of infectious pulmonary tuberculosis..
Silvestre, Joana; Leitão, Ana; Fonseca, Cândida; Alberca, Dolores; Marques, Filipa; Abreu, Ana; Araújo, Inês; João, Isabel; Aleixo, Ana; Ceia, FátimaIntroduction: The immediate identification of infectious tuberculosis and implementation of effective isolation measures, are a priority of the national policies for disease control. Objectives: To identify clinical predictor's factors related with sputum smear-positive, in patients with pulmonary tuberculosis diagnosis. Population and methods: This was a retrospective study involving 289 patients admitted cons...
Adenosine A2A receptor antagonists exert motor and neuroprotective effects by d...
Yu, Liqun; Shen, Hai-Ying; Coelho, Joana E.; Araújo, Inês M.; Huang, Qing-Yuan; Day, Yuan-Ji; Rebola, Nelson; Canas, Paula M.; Rapp, Erica KirstenTo investigate whether the motor and neuroprotective effects of adenosine A2A receptor (A2AR) antagonists are mediated by distinct cell types in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) model of Parkinson's disease.We used the forebrain A2AR knock-out mice coupled with flow cytometric analyses and intracerebroventricular injection to determine the contribution of A2ARs in forebrain neurons and gl...
Intracellular signaling mechanisms mediating catecholamine release upon activat...
Rosmaninho-Salgado, Joana; Araújo, Inês M.; Álvaro, Ana Rita; Duarte, Emília P.; Cavadas, CláudiaThe adrenal chromaffin cells synthesize and release catecholamine (mostly epinephrine and norepinephrine) and different peptides, such as the neuropeptide Y (NPY). NPY stimulates catecholamine release through NPY Y1 receptor in mouse chromaffin cells. The aim of our study was to determine the intracellular signaling events coupled to NPY Y1 receptor activation that lead to stimulation of catecholamine release f...
Reduced hippocampal neurogenesis in R6/2 transgenic Huntington's disease mice
Gil, Joana M. A. C.; Mohapel, Paul; Araújo, Inês M.; Popovic, Natalija; Li, Jia-Yi; Brundin, Patrik; Petersén, ÅsaWe investigated whether cell proliferation and neurogenesis are altered in R6/2 transgenic Huntington's disease mice. Using bromodeoxyuridine (BrdU), we found a progressive decrease in the number of proliferating cells in the dentate gyrus of R6/2 mice. This reduction was detected in pre-symptomatic mice, and by 11.5 weeks, R6/2 mice had 66% fewer newly born cells in the hippocampus. The results were confirmed ...
Early calpain-mediated proteolysis following AMPA receptor activation compromis...
Araújo, Inês M.; Verdasca, Maria J.; Leal, Ermelindo C.; Bahr, Ben A.; Ambrósio, António F.; Carvalho, Arsélio P.; Carvalho, Caetana M.http://dx.doi.org/10.1111/j.1471-4159.2004.03043.x
Neurotoxicity Induced by Antiepileptic Drugs in Cultured Hippocampal Neurons: A...
Araújo, Inês M.; Ambrósio, António Francisco; Leal, Ermelindo C.; Verdasca, Maria João; Malva, João Oliveira; Soares-da-Silva, PatrícioPurpose: Newly designed antiepileptic drugs (AEDs) are being evaluated for their efficacy in preventing seizures and for their toxic profiles. We investigated and compared the toxic effects of two dibenz[b,f]azepine derivatives with anticonvulsant activity, 10,11-dihydro-10-hydroxyimino-5H-dibenz[b,f]azepine-5-carboxamide (BIA2-024) and (S)-(-)-10-acetoxy-10,11-dihydro-5H-dibenz[b,f] azepine-5-carboxamide (BIA2...
Neurotoxic/neuroprotective profile of carbamazepine, oxcarbazepine and two new ...
Ambrósio, António F.; Silva, Ana P.; Araújo, Inês; Malva, João O.; Soares-da-Silva, Patrício; Carvalho, Arsélio P.; Carvalho, Caetana M.We investigated and compared the toxicity profile, as well as possible neuroprotective effects, of some antiepileptic drugs in cultured rat hippocampal neurons. We used two novel carbamazepine derivatives, (S)-(-)-10-acetoxy-10,11-dihydro-5H-dibenz[b,f]azepine-5-carboxamide (BIA 2-093) and 10,11-dihydro-10-hydroxyimino-5H-dibenz[b,f]azepine-5-carboxamide (BIA 2-024), and compared their effects with the establis...
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