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Characterization of alpha thalassemic genotypes by multiplex ligation-dependent...
Suemasu,C.N.; Kimura,E.M.; Oliveira,D.M.; Bezerra,M.A.C.; Araújo,A.S.; Costa,F.F.; Sonati,M.F.Alpha-thalassemia is the most common inherited disorder of hemoglobin synthesis. Genomic deletions involving the alpha-globin gene cluster on chromosome 16p13.3 are the most frequent molecular causes of the disease. Although common deletions can be detected by a single multiplex gap-PCR, the rare and novel deletions depend on more laborious techniques for their identification. The multiplex ligation-dependent p...
Peripheral markers of oxidative stress in chronic mercuric chloride intoxication
Gutierrez,L.L.P.; Mazzotti,N.G.; Araújo,A.S.R.; Klipel,R.B.; Fernandes,T.R.G.; Llesuy,S.F.; Belló-Klein,A.The present study was designed to evaluate the time course changes in peripheral markers of oxidative stress in a chronic HgCl2 intoxication model. Twenty male adult Wistar rats were treated subcutaneously daily for 30 days and divided into two groups of 10 animals each: Hg, which received HgCl2 (0.16 mg kg-1 day-1), and control, receiving the same volume of saline solution. Blood was collected at the first, se...
Hepatitis C virus infection in a Brazilian population with sickle-cell anemia
Torres,M.C.M.R.; Pereira,L.M.M.B.; Ximenes,R.A.A.; Araújo,A.S.; Secaf,M.; Rodrigues,S.S.; Bezerra,A.C.S.; Conceição,I.B.; Valença,M.I.B.Patients with sickle-cell anemia submitted to frequent blood transfusions are at risk of contamination with hepatitis C virus (HCV). Determination of HCV RNA and genotype characterization are parameters that are relevant for the treatment of the viral infection. The objective of the present study was to determine the frequency of HCV infection and the positivity for HCV RNA and to identify the HCV genotype in p...
Myocardial antioxidant and oxidative stress changes due to sex hormones
Barp,J.; Araújo,A.S.R.; Fernandes,T.R.G.; Rigatto,K.V.; Llesuy,S.; Belló-Klein,A.; Singal,P.The purpose of the present study was to examine myocardial antioxidant and oxidative stress changes in male and female rats in the presence of physiological sex hormone concentrations and after castration. Twenty-four 9-week-old Wistar rats were divided into four groups of 6 animals each: 1) sham-operated females, 2) castrated females, 3) sham-operated males, and 4) castrated males. When testosterone and estrog...
Historical records processing in the HiTex system
Oliveira, José Nuno; Araújo, A. S.; Silva, Armando Barreiros Malheiro da
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