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Molecular and cellular mechanisms of Mycobacterium avium-induced thymic atrophy
Borges, Margarida; Silva, Palmira Barreira; Flórido, Manuela; Jordan, Michael B.; Neves, Margarida Correia; Appelberg, RuiThymic atrophy has been described as a consequence of infection by several pathogens and shown to be induced through diverse mechanisms. Using the mouse model of Mycobacterium avium infection, we show in this study that the production of NO from IFN-γ–activated macrophages plays a major role in mycobacterial infection-induced thymic atrophy. Our results show that disseminated infection with a highly virulent st...
Mycobacteria-induced anaemia revisited : a molecular approach reveals the invol...
Rodrigues, Pedro; Gomes, Sandro S.; Neves, João V.; Pereira, Sandra Gomes; Neves, Margarida Correia; Alves, Cláudio Nunes; Stolte, Jens; Sanchez, MaykaAnaemia is a frequent complication of chronic infectious diseases but the exact mechanisms by which it develops remain to be clarified. In the present work, we used a mouse model of mycobacterial infection to study molecular alterations of iron metabolism induced by infection. We show that four weeks after infection with Mycobacterium avium BALB/c mice exhibited a moderate anaemia, which was not accompanied by ...
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