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Educação em saúde: ensinando sobre a leishmaniose tegumentar americana
Uchôa,Claudia Maria Antunes; Serra,Cathia Maria Barrientos; Magalhães,Ciléia de Melo; Silva,Roger Magno Macedo da; Figliuolo,Letícia PintoOs conhecimentos sobre a circulação da leishmaniose tegumentar americana (LTA), assim como sua percepção pela população local, são de grande valia para o estabelecimento de campanhas de controle, pois mobiliza a comunidade em ações sanitárias. Este trabalho teve como objetivo esclarecer alunos e professores do ensino fundamental (1ª a 4ª série) das Escolas Municipais de Maricá sobre a LTA, por meio de palestras...
Cholesterol modulates amiodarone-membrane interactions in model and native memb...
Antunes-Madeira, Maria; Videira, Romeu; Madeira, VítorAbstract The effects of cholesterol, a lipid mostly found in the sarcolemmal membranes, on the interaction of amiodarone with synthetic models of dimyristoylphosphatidylcholine (DMPC) and with native models of mitochondria and brain microsomes was studied. Alterations on the structural order of lipids were assessed by fluorescence polarization of 1,6-diphenyl-1,3,5-hexatriene (DPH) probing the bilayer core, an...
Ethylazinphos Interaction with Membrane Lipid Organization Induces Increase of ...
Videira, Romeu A.; Antunes-Madeira, Maria C.; Madeira, Vítor M. C.Ethylazinphos increases the passive proton permeability of lipid bilayers reconstituted with dipalmitoylphosphatidylcholine (DPPC) and mitochondrial lipids. A sharp increase of proton permeability is detected at insecticide/lipid molar ratios identical to those inducing phase separation in the plane of DPPC bilayers, as revealed by differential scanning calorimetry (DSC). Ethylazinphos progressively depresses t...
Changes induced by malathion, methylparathion and parathion on membrane lipid p...
Videira, Romeu A.; Antunes-Madeira, Maria C.; Lopes, Virgínia I. C. F.; Madeira, Vítor M. C.Perturbations induced by malathion, methylparathion and parathion on the physicochemical properties of dipalmitoylphosphatidylcholine (DPPC) were studied by fluorescence anisotropy of DPH and DPH-PA and by differential scanning calorimetry (DSC). Methylparathion and parathion (50 [mu]M) increased the fluorescence anisotropy evaluated by DPH-PA and DPH, either in gel or in the fluid phase of DPPC bilayers, but m...
Lipid composition and dynamics of cell membranes of Bacillus stearothermophilus...
Rosa, Sónia M. L. J.; Antunes-Madeira, Maria do Carmo; Matos, Manuel J.; Jurado, Amália S.; Madeira, Vítor M. C.Bacillus stearothermophilus, a useful model to evaluate membrane interactions of lipophilic drugs, adapts to the presence of amiodarone in the growth medium. Drug concentrations in the range of 1-2 [mu]M depress growth and 3 [mu]M completely suppresses growth. Adaptation to the presence of amiodarone is reflected in lipid composition changes either in the phospholipid classes or in the acyl chain moieties. Sign...
Amiodarone interactions with membrane lipids and with growth of Bacillus stear...
Rosa, Sónia; Antunes-Madeira, Maria; Jurado, Amália; Madeira, VítorAbstract The thermophilic eubacterium Bacillus stearothermophilus was used as a model to study the effects of amiodarone (2-butyl-3-[3',5'diido-4'a-diethyl-aminoethoxybenzoyl]-benzofuran) in lipid organization and in bacterial growth. Effects on the structural order of lipids were assessed by fluorescence polarization of 1,6-diphenyl-1,3,5-hexatriene (DPH), probing the bilayer core, and of the propionic acid d...
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