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Chronic ketamine administration impairs mitochondrial complex I in the rat liver.
Venâncio, Carlos; Antunes, Luís; Félix, Luís; Rodrigues, Paula; Summaville, Teresa; Peixoto, FranciscoAIM: Ketamine can induce hepatotoxicity which has been suggested to be dependent on mitochondrial impairment. This study investigated the long-term effects of chronic low-dose ketamine on liver mitochondrial function, oxidative stress parameters, liver histology and glycogen content. MAIN METHODS: Adult rats were administered with saline or ketamine (5 or 10mg/kg) twice a day for a fourteen-day period in orde...
Data: 2013
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Origem: Repositório da UTAD
A single intraperitoneal injection of different doses of ketamine did not induc...
Ribeiro, Patrícia; Rodrigues, Paula; Antunes, LuísThis study showed that a single intraperitoneal injection of ketamine did not induced necrosis or apoptosis in liver of adult mice. ; Portuguese Foundation for Science and Technology (Lisbon, Portugal) and co-funded by the COMPETE: -01-0124- FEDER -009497
Data: 2013
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Origem: Repositório da UTAD
