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Avanços na Terapêutica Anti-Retrovírica
Antunes, FranciscoA síndrome de imunodeficiência adquirida (SIDA), apesar dos esforços aplicados na prevenção e dos sucessos da terapêutica antiretrovírica (TARV) continua a ser um problema sério de Saúde Pública. Assim, mantêm-se o empenhamento no desenvolvimento de novos anti-retrovíricos (ARVs) e de novas estratégias terapêuticas. Novos ARVs encontram-se em fase adiantada de investigação clínica. As novas estratégias da TARV ...
Resistance to antibody neutralization in HIV-2 infection occurs in late stage d...
Marcelino, José Maria; Borrego, Pedro; Nilsson, Charlotta; Família, Carlos; Barroso, Helena; Maltez, Fernando; Doroana, Manuela; Antunes, FranciscoObjectives: To characterize the nature and dynamics of the neutralizing antibody (NAb) response and escape in chronically HIV-2 infected patients. ; Methods: Twenty-eight chronically infected adults were studied over a period of 1-4 years. The neutralizing activity of plasma IgG antibodies against autologous and heterologous primary isolates was analyzed using a standard assay in TZM-bl cells. Coreceptor usage...
Baseline susceptibility of primary HIV-2 to entry inhibitors
Borrego, Pedro; Calado, Rita; Marcelino, José M; Bártolo, Inês; Rocha, Cheila; Cavaco-Silva, Patrícia; Doroana, Manuela; Antunes, FranciscoBackground: The baseline susceptibility of primary HIV-2 to maraviroc (MVC) and other entry inhibitors is currently unknown. ; Methods: The susceptibility of 19 HIV-2 isolates obtained from asymptomatic and AIDS patients and seven HIV-1 clinical isolates to the fusion inhibitors enfuvirtide (ENF) and T-1249, and to the coreceptor antagonists AMD3100, TAK-779 and MVC, was measured using a TZM-bl cellbased assay...
Projecto de execução da passagem superior 9A, na concessão Douro Litoral na A32...
Antunes, Francisco Miguel DomingosO presente trabalho teve como principal objectivo a aplicação dos conceitos adquiridos nas unidades curriculares da licenciatura e do mestrado. Nesse sentido tomou-se a opção da realização de um projecto de execução de uma obra de arte para o trabalho final de mestrado, realizado num conceituado gabinete de projecto de pontes e viadutos, com vista à obtenção do grau de mestre. O projecto refere-se a uma obra de...
Cell-associated viral burden provides evidence of ongoing viral replication in ...
Soares, Rui S.; Tendeiro, Rita; Foxall, Russell B.; Baptista, António P.; Cavaleiro, Rita; Gomes, Perpétua; Camacho, Ricardo; Valadas, EmíliaCopyright © 2011, American Society for Microbiology. All Rights Reserved. ; Viremia is significantly lower in HIV-2 than in HIV-1 infection, irrespective of disease stage. Nevertheless, the comparable proviral DNA burdens observed for these two infections indicate similar numbers of infected cells. Here we investigated this apparent paradox by assessing cell-associated viral replication. We found that untreate...
Information management in distributed collaborative systems: The case of collab...
Antunes, Francisco; Melo, Paulo; Costa, João PauloThis paper presents the Collaboration Studio (CS) system, its argumentation and data-structuring models and gives some insights for dealing with information divergence. The system allows discussions among a group of participants that includes a coordinator. The working mechanisms implemented within CS are perfectly transparent to the user, hiding implementation details, giving an appealing and user-friendly env...
Pneumocystis jiroveci infection in immunocompetent patients with pulmonary diso...
Matos, Olga; Costa, Marina Célia; Correia, Isabel; Monteiro, Paula; Vieira, Jorge Roldão; Soares, Jorge; Bonnet, Marina; Esteves, FranciscoThe use of molecular tools with a great capacity to detect and differentiate strains of Pneumocystis has resulted: in the identification of low numbers of P. jiroveci organisms in clinically silent, colonized, immunocompromised patients and in immunocompetent persons. Considering this information, the aim of this study was to determine the prevalence of P. jiroveci carriers (subclinical infections) in Portugues...
Identification and determination of the viability of Giardia lamblia cysts and ...
Lemos, Vanessa; Graczyk, Thaddeus; Alves, Margarida; Lobo, Maria; Sousa, Maria; Antunes, Francisco; Matos, OlgaIn the present study, fluorescent in situ hybridization (FISH) and monoclonal antibodies (MAbs) were evaluated for species-specific detection and viability determination of Giardia lamblia, Cryptosporidium parvum, and Cryptosporidium hominis in human fecal and water supply samples. A total of 50 fecal human samples positive for G. lamblia cysts, 38 positive for C. parvum, and 23 positive for C. hominis were stu...
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