The regulatory mechanisms by which hydrogen peroxide (H2O2) modulates the activity of transcription factors in bacteria (OxyR and PerR), lower eukaryotes (Yap1, Maf1, Hsf1 and Msn2/4) and mammalian cells (AP-1, NRF2, CREB, HSF1, HIF-1, TP53, NF-κB, NOTCH, SP1 and SCREB-1) are reviewed. The complexity of regulatory networks increases throughout the phylogenetic tree, reaching a high level of complexity in mammal...
Tese de mestrado. Engenharia da Segurança e Higiene Ocupacionais. Faculdade de Engenharia. Universidade do Porto. 2009
Estágio realizado na Jayme da Costa-Meânica e Electricidade, S.A. e orientado pelo Eng.º Carlos Manuel da Silva Cardoso ; Tese de mestrado integrado. Engenharia Química. Faculdade de Engenharia. Universidade do Porto. 2008
Nitric oxide (NO) is a ubiquitous diffusible messenger in the central nervous system. NO and derived nitrogen species may interact with catecholamines, thus, modifying not only its regulatory actions but also producing oxidants and free radicals that are likely to trigger toxic pathways in the nervous system. Oxidative pathways and chain oxidation reactions triggered by catecholamines may be broken by ascorbate...
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