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Alterações na actividade enzimática da amílase salivar em indivíduos obesos
Simões, Carla; Costa, Ana Rodrigues; Antunes, Célia M; Lamy, ElsaNos últimos anos o estudo da composição proteica da saliva ganhou interesse pelo seu potencial no diagnóstico não invasivo e compreensão de diversas doenças, quer orais, quer sistémicas. Para além disso, a interacção deste fluido com os constituintes dos alimentos tornam a sua análise importante para a compreensão das variações a nível da percepção dos alimentos e escolhas alimentares. Há, contudo, poucos estud...
Avaliação das alterações na sensibilidade para os gostos doce e amargo em ratos...
Pinheiro, Sandra; Rodrigues, Lenia; Costa, Ana R; Antunes, Célia M; Silva, Fernando C; Lamy, ElsaA obesidade é actualmente considerada uma epidemia estando associada a uma predisposição genética do indivíduo e a um consumo energético desadequado O consumo de alimentos ricos em gordura é um dos factores que contribui para o ganho de peso e obesidade. O gosto é um factor determinante na escolha de alimentos e variações individuais na sensibilidade gustativa podem condicionar os hábitos alimentares. O present...
Glucose-evoked Na+,K+-ATPase modulation in pancreatic ß-cells from normal and i...
Roque, Cátia; Costa, Ana R; Antunes, Célia MNa+,K+-ATPase is regulated by glucose in pancreatic ß-cells, a process that is altered in glucose impaired tolerance. Although AMP dependent protein kinase (AMPK), a metabolic sensor, is believed to be central in the signal transduction cascade underlying the Na+,K+-ATPase regulation in pancreatic β-cells, its role remains unknown. The aim of this work was to clarify the role of AMPK in glucoseevoked inhibition...
Avaliação e Caraterização da Ação Inibitória de Iminociclitóis na Atividade α-G...
Louro, Patricia R; Vannuchi, Nicholas; Carreiro, Elisabete P; Costa, Ana R; Burke, Anthony J; Antunes, Célia MA diabetes, em particular a diabetes mellitus tipo 2, constitui um distúrbio metabólico que se carateriza por glicemias aumentadas resultantes de diminuição da libertação e/ou ação da insulina. Os inibidores das α-glucosidases surgem como agentes de elevado interesse terapêutico uma vez que podem contribuir para a diminuição da absorção intestinal de glicose e, consequentemente, para um desagravamento da hiperg...
Differences in salivary α-amylase levels among women with different taste sensi...
Sequeira, Márcia; Rodrigues, Lénia; Costa, Ana R; Pinheiro, C; Antunes, Célia M; Lamy, ElsaSaliva is the main component of taste receptor cells external environment, and consequently it may have a decisive role in taste perception. Taste sensitivity varies among different individuals. Sensitivity to the compound n-6-propylthiouracil (PROP) has been considerably studied and besides the known influence of genetic background, the contribution of perireceptor environment is not completely clear yet. Sali...
Differential Ole e 1 Release from Olea Airborne Pollen in the Southwest Iberian...
Antunes, Celia M.; Galán, Carmen; Ferro, Raquel; Torres, Carmen; Caeiro, Elsa; Garcia-Mozo, Herminia; Brandao, Rui M.; Buters, Jeroen MBackground: Ole e 1 is the major allergen of olive pollen (Olea europaea L.), the second largest cause of pollinosis in some areas from the Mediterranean Region. Although it has been assumed that airborne pollen is a representative parameter for allergen exposure, variability of allergen content and/or release from pollen has been demonstrated for other taxa. The aim of this study was to: i) estimate the correl...
Grass Pollen Count and Grass group 5-allergen Release across Eight European Cou...
Buters, Jeroen M.; Albertini, Roberto; Annesi-Maesano, Isabella; Antunes, Celia M.; Berger, Uwe; Brandao, Rui M.; Cecchi, Lorenzo; Celenk, SevcanBackground: Grass pollen is considered to be the most important outdoor aeroallergen in Europe. The grass ‘pollen count’ is usually used as a proxy for exposure. However, HIALINE has shown that the birch and olive pollen count is not always congruent with allergen concentrations. We therefore simultaneously measured daily exposure to grass pollen and the concentration of group 5 major allergens across eight cou...
Protein Electrophoresis in Saliva Study
Lamy, Elsa; Costa, Ana R; Antunes, Celia M; Vitorino, Rui; Amado, FranciscoThe following sections will give an overview about the use of electrophoresis in saliva studies. Methodological issues and the major advantages and limitations for the use of this technique in human and animal saliva studies will be presented. We will finish the chapter by presenting alternatives to electrophoresis for the study of salivary proteome.
Isoenzymatic expression of Na, K-ATPase in Langerhans islets of glucose intoler...
Costa, Ana R; Capela e Silva, Fernando; Antunes, Célia M; Cruz Morais, Júlio MNa,K-ATPase is ubiquitously expressed in all eukaryotic cells where it acts as a regulator of Na+ and K+ homeostasis. The Na,K-ATPase pump consists of (αβ)22. The α-subunit contains the catalytic and ligand binding sites. The β-subunit is a glycosylated protein, and its role in Na,K-ATPase enzyme function remains somewhat obscure. Four α- and three β-isoforms have been described in mammals. The isoenzymatic exp...
Abnormal regulation of pancreatic beta cell Na,K-ATPase on glucose intolerant rats
Rodrigues Costa, Ana; Antunes, Celia M; Cruz-Morais, JúlioBackground and aims: Glucose (G) is the most important physiological insulin secretagogue. It is widely accepted that, in pancreatic -cell, G evoked early ionic events such as membrane depolarization and Ca2+ influx through voltage dependent Ca2+ channels triggers insulin exocytosis. However, the role of other electrogenic systems, namely ionic pumps, to these events remains essentially uninvestigated. It is k...
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