Encontrados 14 documentos, a visualizar página 1 de 2
Thrombotic recurrent events after cerebral vein thrombosis
Miranda, Bruno André e Silva, 1982-Tese de mestrado, Neurociências, Faculdade de Medicina, Universidade de Lisboa, 2011 ; Introdução: Após uma trombose dos seios venosos cerebrais (TSV), o risco de recorrência trombótica está aumentado. O tempo até um segundo evento trombótico e os factores de risco associados à recorrência não foram adequadamente avaliados em estudos prospectivos. Métodos: Foram utilizados dados do International Study on Cereb...
Effects of children obesity on wound healing capacity and on oral epithelium
Gilberto André e SilvaObesity in childhood has becoming a concern. Obesityy is associated with increased triglycerides, decreased high-density lipoprotein cholesterol levels, and increased low-density lipoprotein cholesterol and may lead to increased risk for hypercholesterolemia and cardiovascular complications in adult life. Clinical symptoms and signs of elevated cholesterol levels do not occur until adulthood, but subclinical as...
In vivo MRI assessment of a novel GdIII-based contrast agent designed for high ...
Sousa, Paulo Loureiro de; Livramento, João Bruno; Helm, Lothar; Merbach, André E.; Même, William; Doan, Bich-Thuy; Beloeil, Jean-ClaudeGd3L is a trinuclear Gd3+ complex of intermediate size, designed for contrast agent applications in high field magnetic resonance imaging (H12L is based on a trimethylbenzene core bearing three methylene-diethylenetriamine- N,N,NPrimeNPrime-tetraacetate moieties). Thanks to its appropriate size, the presence of two inner sphere water molecules and a fast water exchange, Gd3L has remarkable proton relaxivities a...
Supramolecular Assembly of an Amphiphilic GdIII Chelate: Tuning the Reorientati...
Torres, Susana; Martins, José A.; André, João P.; Geraldes, Carlos F. G. C.; Merbach, André E.; Tóth, ÉvaWe report the synthesis and characterization of the novel ligand H5EPTPA-C16 ((hydroxymethylhexadecanoyl ester)ethylenepropylenetriaminepentaacetic acid). This ligand was designed to chelate the GdIII ion in a kinetically and thermodynamically stable way while ensuring an increased water exchange rate (kex) on the GdIII complex owing to steric compression around the water-binding site. The attachment of a palmi...
Supramolecular assembly of an amphiphilic GdIII chelate : tuning the reorientat...
Torres, Susana; Martins, J. A. R.; André, João P.; Geraldes, Carlos F. G. C.; Merbach, André E.; Tóth, ÉvaIn this paper we report the synthesis and the characterization of the novel ligand H5EPTPA-C16 ((hydroxymethylhexadecanoyl ester)ethylenepropylenetriaminepentaacetic acid). This ligand was designed to chelate the GdIII ion in a kinetically and thermodynamically stable way while ensuring an increased water exchange rate (kex) on the GdIII complex due to steric compression around the water binding site. The attac...
Lanthanide(III) Chelates of DTPA Bis(amide) Glycoconjugates: Potential Imaging ...
Baía, Paula; André, João P.; Geraldes, Carlos F. G. C.; Martins, José A.; Merbach, André E.; Tóth, ÉvaThe synthesis and characterisation of a new class of DTPA bis(amide) linked glycoconjugates of different sugars [lactose (Lac) and galactose (Gal)] and valencies (di and tetra) and their LnIII complexes is reported. The 1H NMR spectra of the SmIII and EuIII complexes of DTPAGal2, DTPAGal4, and DTPALac2, obtained between 7 and 80 °C, indicate that several of the four possible diastereoisomeric pairs of structure...
Lanthanide(III) chelates of DTPA-bisamide glycoconjugates : potential imaging a...
Baía, Paula; André, João P.; Geraldes, Carlos F. G. C.; Martins, J. A. R.; Merbach, André E.; Tóth, ÉvaThe synthesis and characterization of a new class of DTPA bisamide-linked glycoconjugates of different sugars (lactose, Lac, and galactose, Gal) and valencies (di and tetra) and their Ln(III) complexes is reported. The 1H NMR spectra of the Sm(III) and Eu(III) complexes of DTPAGal2, DTPAGal4, and DTPALac2 obtained between 7 and 80 ºC, indicate that most (if not all) of the four possible diastereoisomeric pairs ...
Lanthanide(III) Complexes of DOTA-Glycoconjugates: A Potential New Class of Lec...
André, João P.; Geraldes, Carlos F. G. C.; Martins, José A.; Merbach, André E.; Prata, Maria I. M.; Santos, Ana C.; Lima, João J. P. de; Tóth, ÉvaThe synthesis and characterization of a new class of DOTA (1,4,7,10-tetrakis(carboxymethyl)-1,4,7,10-tetraazacyclododecane) monoamide-linked glycoconjugates (glucose, lactose and galactose) of different valencies (mono, di and tetra) and their SmIII, EuIII and GdIII complexes are reported. The 1H NMR spectrum of EuIII-DOTALac2 shows the predominance of a single structural isomer of square antiprismatic geometry...
Lanthanide(III) complexes of DOTA-glycoconjugates : a potential new class of le...
André, João P.; Geraldes, Carlos F. G. C.; Martins, J. A. R.; Merbach, André E.; Prata, M. I. M.; Santos, A. C.; Lima, J. J. Pedroso de; Tóth, ÉvaThe synthesis and characterization of a new class of DOTA (1,4,7,10-tetrakis(carboxymethyl)-1,4,7,10-tetraazacyclododecane) monoamide-linked glycoconjugates (glucose, lactose and galactose) of different valencies (mono, di and tetra) and their Sm(III), Eu(III) and Gd(III) complexes are reported. The proton NMR spectrum of Eu(III)-DOTALac(III) shows the predominance of a single structural isomer of square ...
Frações de zinco em solo arenoso e suas relações com disponibilidade para Cynod...
André,E. M.; Cruz,M. C. P.; Ferreira,M. E.; Palma,L. A. S.Para avaliar um esquema de fracionamento de zinco em Argissolo arenoso e suas relações com a disponibilidade de Zn para Cynodon spp cv. Tifton-85, realizou-se um experimento em casa de vegetação, em esquema fatorial 5 x 2 x 2 (5 doses de Zn, 2 doses de calcário e 2 épocas de amostragem), em delineamento inteiramente casualizado, com três repetições. As doses de Zn foram de 0; 2,5; 5,0; 7,5 e 10 mg dm-3; metade ...
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