Encontrados 5 documentos, a visualizar página 1 de 1
ERBB2 in Cat Mammary Neoplasias Disclosed a Positive Correlation between RNA an...
Santos, Sara; Batista, Claudia; Abreu, Rui M.V.; Bastos, Estela; Amorim, Irina; Gut, Ivo G.; Gartner, Fátima; Chaves, RaquelHuman ERBB2 is a proto-oncogene that codes for the erbB-2 epithelial growth factor receptor. In human breast cancer (HBC), erbB-2 protein overexpression has been repeatedly correlated with poor prognosis. In more recent works, underexpression of this gene has been described in HBC. Moreover, it is also recognised that oncogenes that are commonly amplified or deleted encompass point mutations, and some of these ...
In vivo evaluation of the potencial of mesenchymal stem cells (MSCs) from whart...
Alexandre, Nuno; Lopes, Ascensão; Rodrigues, Miguel; Amorim, Irina; Pereira, Tiaho; Gärtner, Andrea; Maurício, Ana Colette; Santos, José DomingosIntroduction: The use of cellular systems for improving biointegration of medical devices is a current trend of tissue engineering. The biocompatibility is a key aspect that can influence the performance of medical devices, for that reason inflammatory and foreign body reaction must be evaluated in pre-clinical studies. MSCs can modify the interaction of biomaterials with tissues by several mechanisms through t...
Application of Vascular grafts od Polyvinyl alcohol hydrogel associated to mese...
Alexandre, Nuno; Lopes, Ascensão; Nunes, Natacha; Amorim, Irina; Maurício, Ana Colette; Santos, José Domingos; Luís, Ana LúciaApplication of vascular grafts of the polyvinyl alcohol hydrogel (PVA) associated with MSCs from Wharton jelly in an animal model (sheep). N Alexandre, MA Lopes, N Fernandes, M Rodrigues, I Amorim, AC Mauricio, AL Luís Introduction: There is a great demand for new artificial vascular grafts of small diameter (< 6 mm) due to the functional limitations of the currently used biomaterials (ePTFE and Dacron). Polyv...
Biological evaluation of alginate-based hydrogels, with antimicrobial features ...
Morais, D. S.; Rodrigues, M. A.; Lopes, M. A.; Coelho, M. J.; Maurício, Ana Colete; Gomes, R.; Amorim, Irina; Ferraz, M. P.; Santos, J. D.In this work three different hydrogels were developed to associate, as vehicles, with the synthetic bone substitute GR-HA. One based on an alginate matrix (Alg); a second on a mixture of alginate and chitosan (Alg/Ch); and a third on alginate and hyaluronate (Alg/HA), using Ca2+ ions as cross-linking agents. The hydrogels, as well as the respective injectable bone substitutes (IBSs), were fully characterized fr...
Application of artificial vascular polyvinyl alcohol hydrogel grafts in sheep -...
Alexandre, Nuno; Gärtner, Andrea; Amorim, Irina; Santos, José D.; Lopes, Maria Ascensão; Colette Maurício, Ana; Luís, Ana LúciaResearchers developed this project according with the tasks originally planned, so far focusing their research activities in the biocompatibility and functionality of vascular implants. The biocompatibility was studied by following the ISO standard 10993-6 for evaluation of medical devices through the evaluation and grading of inflammation caused by implants placed subcutaneously. The implants were placed in sh...
| Financiadores do RCAAP | |||||||
|
|
|
|
|
|
||