Encontrados 3 documentos, a visualizar página 1 de 1
P-Cadherin as Prognostic Factor for Loco-Regional Relapse in Breast Cancer
Faria, Gil; Cardoso, Maria João; Martins, Diana; Bettencourt, Herberto; Amendoeira, Isabel; Schimitt, FernandoBackground: Breast cancer is the most frequent malignant tumor and the leading cause of cancer death in women in Portugal. Due to its relation to an increase in distant metastasis and subsequent death, loco-regional relapse is one major concern in breast cancer women. Several classic prognostic factors as tumour size, nodal stage, histological grade, HER2 status and hormonal receptors have been identified as th...
Distribution of p63, a novel myoepithelial marker, in fine-needle aspiration bi...
Reis Filho, Jorge S.; Milanezi, Fernanda; Amendoeira, Isabel; Albergaria, André; Schmitt, Fernando C.BACKGROUND. The presence of myoepithelial cells (MECs) in fine-needle aspiration biopsies (FNAB) of the breast constitute an important criterion used to diagnose benign breast lesions. However, MECs sometimes have a distorted cytomorphology, and most of the previously evaluated myoepithelial markers do not have satisfactory sensitivity and specificity. p63, a recently characterized p53 homolog, is a nuclear tra...
Naked nuclei revisited : p63 immunoexpression
Reis Filho, Jorge S.; Albergaria, André; Milanezi, Fernanda; Amendoeira, Isabel; Schmitt, Fernando C.The presence of naked nuclei (NN) in cytological preparations of fibroadenomas is a well-known finding. Regardless of their importance on the differential diagnosis of fibroadenoma and other benign lesions of the breast, the origin of NN remains elusive. Despite previous efforts to characterize them, the lack of a reliable nuclear marker for myoepithelial cells impaired definitive conclusions. We performed a sy...
| Financiadores do RCAAP | |||||||
|
|
|
|
|
|
||