Encontrados 19 documentos, a visualizar página 1 de 2
Doença de Hodgkin na Criança. Experiência de 10 Anos
Costa, Paula Lopes da; Lacerda, Ana Forjaz de; Vieira, Ester; Chagas, Mário; Ambrósio, António; Neto, Ana; Pereira, Filomena; Ribeiro, Maria JoséObjectivos: Caracterizar os casos de Doença de Hodgkin (DH) seguidos no Serviço de Pediatria do Instituto Português de Oncologia de Francisco Gentil — Centro de Lisboa (IPOFG-L) e avaliar a eficácia e efeitos secundários do tratamento.Métodos: Análise retrospectiva dos processos clínicos dos doentes admitidos com DH no IPOFG-L entre Janeiro de 1987 e Dezembro de 1996.Resultados: Foram estudados 53 doentes (40M/...
Emerging novel roles of neuropeptide Y in the retina: from neuromodulation to n...
Santos-Carvalho, Ana; Álvaro, Ana Rita; Martins, João; Ambrósio, António Francisco; Cavadas, CláudiaNeuropeptide Y (NPY) and NPY receptors are widely expressed in the central nervous system, including the retina. Retinal cells, in particular neurons, astrocytes, and Müller, microglial and endothelial cells express this peptide and its receptors (Y1, Y2, Y4 and/or Y5). Several studies have shown that NPY is expressed in the retina of various mammalian and non-mammalian species. However, studies analyzing the d...
Evaluation of neurotoxic and neuroprotective pathways affected by antiepileptic...
Morte, Maria I.; Carreira, Bruno P.; Falcão, Maria J.; Ambrosio, António M.; Soares-da-Silva, Patrício; Araújo, Inês M.; Carvalho, Caetana M.In this study we evaluated the neurotoxicity of eslicarbazepine acetate (ESL), and of its in vivo metabolites eslicarbazepine (S-Lic) and R-licarbazepine (R-Lic), as compared to the structurally-related compounds carbamazepine (CBZ) and oxcarbazepine (OXC), in an in vitro model of cultured rat hippocampal neurons. The non-related antiepileptic drugs (AEDs) lamotrigine (LTG) and sodium valproate (VPA) were also ...
Diabetes induces early transient changes in the content of vesicular transporte...
Baptista, Filipa I.; Gaspar, Joana M.; Cristóvão, Armando; Santos, Paulo F.; Köfalvi, Attila; Ambrósio, António F.Diabetes induces changes in neurotransmitter release in central nervous system, which depend on the type of neurotransmitter and region studied. In this study, we evaluated the effect of diabetes (two and eight weeks duration) on basal and evoked release of [14C]glutamate and [3H]GABA in hippocampal and retinal synaptosomes. We also analyzed the effect of diabetes on the protein content of vesicular glutamate a...
Diabetes changes the levels of ionotropic glutamate receptors in the rat retina
Santiago, Ana R.; Gaspar, Joana M.; Baptista, Filipa I.; Cristóvão, Armando J.; Santos, Paulo F.; Kamphuis, Willem; Ambrósio, António F.Purpose: Diabetic retinopathy (DR) is a leading cause of vision loss and blindness among adults between the age 20 to 74. Changes in ionotropic glutamate receptor subunit composition can affect retinal glutamatergic neurotransmission and, therefore, contribute to visual impairment. The purpose of this study was to investigate whether diabetes leads to changes in ionotropic glutamate receptor subunit expression ...
Diabetes changes ionotropic glutamate receptor subunit expression level in the ...
Santiago, Ana R.; Hughes, John M.; Kamphuis, Willem; Schlingemann, Reinier O.; Ambrósio, António F.Early diabetic retinopathy is characterized by changes in subtle visual functions such as contrast sensitivity and dark adaptation. The outcome of several studies suggests that glutamate is involved in retinal neurodegeneration during diabetes. We hypothesized that the protein levels of ionotropic glutamate receptor subunits are altered in the retina during diabetes. Therefore, we investigated whether human dia...
High glucose and oxidative/nitrosative stress conditions induce apoptosis in re...
Leal, Ermelindo C.; Aveleira, Célia A.; Castilho, Áurea F.; Serra, Andreia M.; Baptista, Filipa I.; Hosoya, Ken-Ichi; Forrester, John V.http://www.sciencedirect.com/science/article/B6WFD-4V94X19-2/2/49680e499c2d31bd74eb7ad7fc99a8c2
Differential Contribution of L-, N-, and P/Q-type Calcium Channels to [Ca2+]i C...
Santiago, Ana; Carvalho, Caetana; Carvalho, Arsélio; Ambrósio, AntónioAbstract We investigated the contribution of L-, N- and P/Q-type Ca2+ channels to the [Ca2+]i changes, evoked by kainate, in the cell bodies of hippocampal neurons, using a pharmacological approach and Ca2+ imaging. Selective Ca2+ channel blockers, namely nitrendipine, ?-Conotoxin GVIA (?-GVIA) and ?-Agatoxin IVA (?-AgaIVA) were used. The [Ca2+]i changes evoked by kainate presented a high variability, and were...
NPY in rat retina is present in neurons, in endothelial cells and also in micro...
Álvaro, Ana Rita; Rosmaninho-Salgado, Joana; Santiago, Ana Raquel; Martins, João; Aveleira, Célia; Santos, Paulo F.; Pereira, Tiago; Gouveia, DenisaNPY is present in the retina of different species but its role is not elucidated yet. In this work, using different rat retina in vitro models (whole retina, retinal cells in culture, microglial cell cultures, rat Müller cell line and retina endothelial cell line), we demonstrated that NPY staining is present in the retina in different cell types: neurons, macroglial, microglial and endothelial cells. Retinal c...
Inducible nitric oxide synthase isoform is a key mediator of leukostasis and bl...
Leal, Ermelindo C.; Manivannan, Ayyakkannu; Hosoya, Ken-Ichi; Terasaki, Tetsuya; Cunha-Vaz, José; Ambrósio, António Francisco; Forrester, John V.PURPOSE: Nitric oxide (NO) is involved in leukostasis and blood-retinal barrier (BRB) breakdown in the early stages of diabetic retinopathy (DR), but it is unclear which NO synthase (NOS) isoforms are primarily involved. In this study, the authors aimed to clarify the involvement of constitutive (eNOS, nNOS) and inducible NOS (iNOS) isoforms and the mechanisms underlying NO-mediated leukostasis and BRB breakdow...
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