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Neuropeptide Y protects retinal neural cells against cell death induced by ecstasy
Álvaro, A. R.; Martins, J.; Costa, A. C.; Fernandes, E.; Carvalho, F.; Ambrósio, A. F.; Cavadas, C.Ecstasy (3,4-methylenedioxymethamphetamine; MDMA) has potent CNS stimulant effects. Besides the acute effects of MDMA, such as psychomotor activation, euphoria, decreased appetite, and hyperthermia, long-term damage of dopaminergic and serotonergic nerve terminals in multiple brain areas have also been reported. Although some studies have demonstrated that considerable amounts of MDMA reach the vitreous humor o...
Calcium dobesilate prevents changes in tight junction proteins in the retina in...
Leal, E. C.; Martins, J.; Chiavaroli, C.; Cunha-Vaz, J.; Ambrósio, A. F.Purpose Calcium dobesilate has been found to correct the excessive vascular permeability associated with diabetes in the retina of diabetic patients and in experimental diabetes. However, the molecular mechanisms underlying these effects are not elucidated yet. In this study, we investigated the potential protective effect of calcium dobesilate against changes in tight junction proteins (occludin, ZO-1 and clau...
High glucose induces caspase-independent cell death in retinal neural cells
Santiago, A. R.; Cristóvão, A. J.; Santos, P. F.; Carvalho, C. M.; Ambrósio, A. F.Diabetic retinopathy is a leading cause of blindness among adults in the western countries. It has been reported that neurodegeneration may occur in diabetic retinas, but the mechanisms underlying retinal cell death are poorly understood. We found that high glucose increased the number of cells with condensed nuclei and the number of TUNEL-positive cells, and caused an increase in the translocation of phosphati...
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