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Response of high-risk of recurrence/progression bladder tumours expressing sial...
Lima, Luís; Severino, Paulo; Silva, Mariana; Miranda, Andreia; Tavares, Ana; Pereira, Sofia; Fernandes, Elisabete; Cruz, Ricardo; Amaro, TeresinaHigh risk of recurrence/progression bladder tumours is treated with Bacillus Calmette-Guérin (BCG) immunotherapy after complete resection of the tumour. Approximately 75% of these tumours express the uncommon carbohydrate antigen sialyl-Tn (Tn), a surrogate biomarker of tumour aggressiveness. Such changes in the glycosylation of cell-surface proteins influence tumour microenvironment and immune responses that m...
The predominance of M2-polarized macrophages in the stroma of low-hypoxic bladd...
Lima, Luís; Oliveira, Daniela; Tavares, Ana; Amaro, Teresina; Cruz, Ricardo; Ferreira, José Alexandre; Santos, LúcioOBJECTIVE: Bacillus Calmette-Guérin (BCG) immunotherapy is the gold standard treatment for superficial bladder tumors with intermediate/high risk of recurrence or progression. However, approximately 30% of patients fail to respond to the treatment. Effective BCG therapy needs precise activation of the type 1 helper cells immune pathway. Tumor-associated macrophages (TAMs) often assume an immunoregulatory M2 phe...
Overexpression of tumour-associated carbohydrate antigen sialyl-Tn in advanced ...
Ferreira, José Alexandre; Videira, Paula; Lima, Luís; Pereira, Sofia; Silva, Mariana; Carrascal, Milene; Severino, Paulo; Fernandes, ElisabeteLittle is known on the expression of the tumour-associated carbohydrate antigen sialyl-Tn (STn), in bladder cancer. We report here that 75% of the high-grade bladder tumours, presenting elevated proliferation rates and high risk of recurrence/progression expressed STn. However, it was mainly found in non-proliferative areas of the tumour, namely in cells invading the basal and muscle layers. STn was also found ...
A delecção do gene TP53 e a acumulação do p53 (AB-240) são importantes na dete...
Pereira, Sofia; Costa, Céu; Lameiras, Catarina; Amaro, Teresina; Bento, Maria; Koch, Alberto; Santos, Lúcio LaraTP53 gene deletions or mutations were related to more aggressiveness in invasive and in situ bladder tumors. However, its prognostic value in the superficial ones is not well defined. Sixty-two cases with low-grade superficial urothelial cell carcinomas (uccs) were studied. twenty-two suffered recurrence and 10 of these progressed. FiSH for TP53 detection and immunohistochemistry for p53 with both Do7 and Ab-24...
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