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Manifestações oftalmológicas de doenças sistémicas

Pensar em Tuberculose... Isolar o Bacilo. Descrição de 5 Casos e Revisão da Lit...

O diagnóstico de tuberculose na criança exige um elevado índice de suspeição clínica, sendo a confirmação por isolamento bacteriológico menos frequente do que no adulto.Os autores apresentam estudo retrospectivo de 5 casos de crianças internadas por tuberculose (5 caucasianas, 2 sexo masculino, média de idades de 5,5 anos) em que houve confirmação bacteriológica por isolamento do Mycobacterium tuberculosis.O pr...

Tabela Nacional de Funcionalidade (adulto em idade ativa com doença crónica). R...

Na sequência da Resolução da Assembleia da República n.º 90/2010, de 10 de agosto, o Ministério da Saúde incumbiu a Direção-Geral da Saúde de elaborar uma tabela nacional de funcionalidade para pessoas com doenças crónicas, de acordo com a Classificação Internacional de Funcionalidade, Incapacidade e Saúde (CIF) da Organização Mundial de Saúde (OMS). A Direção-Geral da Saúde, ainda em 2010, através do Departam...

Self-mated tribological systems based on multilayer micro/nanocrystalline CVD d...

The tribological response of multilayer micro/nanocrystalline diamond coatings grown by the hot filament CVD technique is investigated. These multigrade systems were tailored to comprise a starting microcrystalline diamond (MCD) layer with high adhesion to a silicon nitride (Si3N4) ceramic substrate, and a top nanocrystalline diamond (NCD) layer with reduced surface roughness. Tribological tests were carried ou...

Cisticercose do tecido mole

Litíase coraliforme

Insuficiência hepato-renal

A DLC/diamond bilayer approach for reducing the initial friction towards a high...

Sliding contact mechanics is used to account for the net increase of the bearing capacity of high wear-resistant CVD diamond coatings when an outer layer of a DLC lubricant film is deposited on their top surface. Experimental results,namely the critical failure load, taken from reciprocating ball-on-plate tribological testing of such DLC/diamond bilayers, are on the basis of this statement. DC magnetron sputter...

Antagonistic Regulation of CFTR Cell Surface Expression by Protein Kinases WNK4...

Members of the WNK (with no lysine (K)) subfamily of protein kinases regulate various ion channels involved in sodium, potassium and chloride homeostasis by either inducing their phosphorylation or regulating the number of channel proteins expressed at the cell surface. Here, we describe that WNK4 promotes the cell surface expression of the cystic fibrosis transmembrane conductance regulator (CFTR) in mammalian...

Contribution of casein kinase 2 and spleen tyrosine kinase to CFTR trafficking ...

Previously, the pleiotropic "master kinase" casein kinase 2 (CK2) was shown to interact with CFTR, the protein responsible for cystic fibrosis (CF). Moreover, CK2 inhibition abolished CFTR conductance in cell-attached membrane patches, native epithelial ducts, and Xenopus oocytes. CFTR possesses two CK2 phosphorylation sites (S422 and T1471), with unclear impact on its processing and trafficking. Here, we inves...