Simulated gastro-intestinal digestion is widely employed in many fields of food and nutritional sciences, as conducting human trials are often costly, resource intensive, and ethically disputable. As a consequence, in vitro alternatives that determine endpoints such as the bioaccessibility of nutrients and non-nutrients or the digestibility of macronutrients (e.g. lipids, proteins and carbohydrates) are used fo...
Mycotoxins are natural fungal metabolites and food contaminants with potential to cause severe acute and chronic conditions. Food contamination with mycotoxins such as aflatoxins (AF) and ochratoxin A (OTA) have been causing great concern, especially due to their potential mutagenic and carcinogenic effects. Children are especially vulnerable to the deleterious effects of these mycotoxins due to their physiolog...
Aflatoxins (AF) and ochratoxin A (OTA) are frequent contaminants of foodstuff and low doses of these mycotoxins have been shown to co-occur in baby foods. Our objective was to investigate whether a combined intake of AFM1 and OTA could alter the cytotoxic and genotoxic effects of the single mycotoxins. These effects were assessed by the Neutral Red and the Comet assays, following exposure of Caco-2 cells to ind...
Financiadores do RCAAP | |||||||
![]() |
![]() |
![]() |
![]() |
![]() |
![]() |