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Polycyclic Aromatic Hydrocarbons May Contibute for Prostate Cancer Progression

Freitas, Mariana; Alves, Vera; Sarmento-Ribeiro, Ana; Mota-Pinto, Anabela

Prostate cancer is the most common form of cancer affecting men in the Western world. Risk factors include ageing, genetics, recurrent inflammation, lifestyle and diet intake, related to an increase of oxidative stress. Prostate cancer risk is also associated with exposure to carcinogen such as polycyclic aromatic hydrocarbons (PAHs), originated from the incomplete combustion of carbon-containing fuels like tob...


CD4+, CD8+ AND CD19+ Cells at Individuals with Dyslipidemia

Pereira de Moura, Jose; Serviço de Medicina Interna. Centro Hospitalar e Universitário de Coimbra. Coimbra. Portugal.

Introduction: The past decade has witnessed an increasing recognition that inflammatory mechanisms play a central role in the pathogenesis of atherosclerosis and its complications. Recently, attention was focused on the potential role of plasma markers of inflammation as risk predictors among those at risk for cardiovascular events. Of these potential markers, C-reactive protein (CRP), IL6, metalloproteinases, ...

Data: 2013   |   Origem: Acta Médica Portuguesa

Populações Celulares Periféricas (CD4+, CD8+ e CD19+) em Indivíduos Dislipidémi...

Pereira de Moura, José; Santos Rosa, Manuel; Alves, Vera; Mota-Pinto, Anabela; Rodrigues, Vítor; Silva, José Manuel; Alves de Moura, JJ

Introdução: Os mecanismos imunológicos e inflamatórios têm um papel crucial no desenvolvimento da aterosclerose e na sua tradução clínica. São inúmeros os estudos que procuraram relacionar os mais diversos marcadores inflamatórios – leucócitos, proteína C reactiva, interleucinas, quimiocinas, moléculas de adesão, metaloproteinases, etc – com os factores de risco clássicos da aterosclerose, a formação da placa e...


Oxidative stress adaptation in aggressive prostate cancer may be counteracted b...

Freitas, Mariana; Baldeiras, Inês; Proença, Teresa; Alves, Vera; Mota-Pinto, Anabela; Sarmento-Ribeiro, Ana Bela

Oxidative stress has been associated with prostate cancer development and progression due to an increase of reactive oxygen species (ROS). However, the mechanisms whereby ROS and the antioxidant system participate in cancer progression remain unclear. In order to clarify the influence of oxidative stress in prostate cancer progression, we performed this study in two human prostate cancer cell lines, PC3 and HPV...


O fundo da Associação Protectora da Infância Desvalida e dos Pobres do Lumiar. ...

Alves, Vera Lúcia Apolinário

Relatório de Estágio apresentado para cumprimento dos requisitos necessários à obtenção do grau de Mestre em Ciências da Informação e Documentação – Arquivística ; O relatório de estágio que aqui se apresenta descreve as actividades realizadas no Arquivo Histórico da Santa Casa da Misericórdia de Lisboa. O estágio incidiu no trabalho de análise e levantamento do conjunto documental da Associação Protectora da ...

Data: 2012   |   Origem: Repositório Institucional da UNL

Rhizosphere properties of maize genotypes with contrasting phosphorus efficiency

Brasil,Edilson Carvalho; Alves,Vera Maria Carvalho; Marriel,Ivanildo Evódio; Pitta,Gilson Villaça Exel; Carvalho,Janice Guedes de

An experiment was conducted in a growth chamber to evaluate characteristics of the rhizosphere of maize genotypes contrasting in P-use efficiency, by determining length and density of root hairs, the rhizosphere pH and the functional diversity of rhizosphere bacteria. A sample of a Red Oxisol was limed and fertilized with N, K and micronutrients. In the treatment with the highest P level, 174 mg kg-1 P was adde...

Data: 2011   |   Origem: OASIS br

Ânforas romanas no concelho de Fronteira. Exemplares recolhidos entre 1999 e 2002

Alves, Vera; Carneiro, André

Apresentam-se os fragmentos de contentores anfóricos que foram recolhidos em escavações e prospecções realizadas nos diversos sítios romanos do concelho de Fronteira. Estabelecem-se quadros tipológicos e considerações sobre os abastecimentos de produtos a esta região.


Aging and asthma - Changes in CD45RA, CD29 and CD95 T cells subsets

Todo-Bom, Ana; Mota-Pinto, Anabela; Alves, Vera; Santos-Rosa, Manuel

Background: Aging is associated with thymus involution leading to a reduction in naive T cells and to an accumulation of effector-memory cells. Apoptosis is a key mechanism to clear the immune system from activated and harmful cells. In asthma the stimulation of T cells by environmental antigens can decrease naive cells and sustain activated cells. The aim of this work was to evaluate the imbalance between CD45...


Combined effect of sodium selenite and docetaxel on PC3 metastatic prostate can...

Freitas, Mariana; Alves, Vera; Sarmento-Ribeiro, Ana Bela; Mota-Pinto, Anabela

Docetaxel and sodium selenite are well known for their anticancer properties. While resistance to docetaxel remains an obstacle in prostate cancer chemotherapy, sodium selenite, has been exploited as a new therapeutic approach. Currently, development of therapies affecting a multitude of cell targets, have been proposed as a strategy to overcome drug resistance. This association may reduce systemic toxicity cou...


Regulatory T Cells in Elderly Patients With Asthma

Mota-Pinto, Anabela; Todo-Bom, Ana; Alves, Vera; Santos, Alexandra; Santos-Rosa, Manuel

Background: Airway walls in asthma present an accumulation of activated cells that determine bronchial structural changes and disease progression and severity. During the aging process, the immunoinflammatory response changes as a consequence of chronic antigenic stress. Objective: To evaluate T-cell subsets with regulatory functions associated with asthma in elderly patients. Methods: A group of 153 individual...


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    Financiadores do RCAAP

Fundação para a Ciência e a Tecnologia Universidade do Minho   Governo Português Ministério da Educação e Ciência Programa Operacional da Sociedade do Conhecimento União Europeia