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Nanostructured polymeric coatings based on chitosan and dopamine-modified hyalu...

In a marine environment, specific proteins are secreted by mussels and used as a bioglue to stick to a surface. These mussel proteins present an unusual amino acid 3,4-dihydroxyphenylalanine (known as DOPA). The outstanding adhesive properties of these materials in the sea harsh conditions have been attributed to the presence of the catechol groups present in DOPA. Inspired by the structure and composition of t...

Estenoses Laríngeas Membranosas — Diagnóstico e Tratamento. A Propósito de Dois...

A estenose sub-glótica é a segunda causa, mais frequente, de estridor laríngeo na criança. Menos de 5% destas estenoses são congénitas.Apresentam-se dois casos clínicos de estenose sub-glótica membranosa congénitas, diagnosticados por fibrolaringoscopia. O diagnóstico foi feito aos dezasseis dias de vida e aos doze meses, sendo o tratamento por cirurgia laser. Mais de um ano após os procedimentos cirúrgicos amb...

Sustained remission from depressive-like behavior depends on hippocampal neurog...

We thank M Carneiro and L Martins for technical assistance. AM-P, LP, MM and SM received fellowships from the Portuguese Foundation for Science and Technology (FCT). This work was supported by FCT (PTDC/SAU-NEU/105180/2008) and the ICVS. ; Impairment of hippocampal neurogenesis has been associated with the expression of depressive-like symptoms and some studies have suggested neurogenesis as a critical factor ...

Chitosan membranes containing micro or nano-size bioactive glass particles : ev...

A newfamilyofbiodegradablepolymer/bioactiveglass(BG)compositematerialshas emergedbasedontheavailabilityofnano-sizedbioactiveparticles.Suchnovelbiocompo- sites canhaveenhancedperformance,intermsofmechanicalpropertiesandbioactivity, and theycanbedesignedtobeusedinboneregenerationapproaches. In thiswork,membranesofchitosan(CTS)andchitosanwithbioactiveglass(BG)both micron andnanosizedparticles(CTS/mBG,CTS/nBG,respe...

Biomineralization in chitosan/Bioglass® composite membranes under different dyn...

Fundamental aspects of biomineralization may be important in order to understand and improve calcification onto the surface of biomaterials. The biomineralization process is mainly followed in vitro by assessing the evolution of the apatite layer that is formed upon immersion of the material in Simulated Body Fluid (SBF). In this work we propose an innovative methodology to monitor apatite deposition by looking...

Polymeric layer-by-layer films composed by natural polymers and based on the ad...

Publicado em "Journal of Tissue Engineering and Regenerative Medicine", vol. 7, supp. 1 (2013) ; Some marine species, such as mussels, can strongly attach themselves to rocks in the diffficult conditions of the sea. In fact, marine mussels secrete adhesive proteins that show a high adhesion to both inorganic and organic surfaces in aqueous environments. These proteins have an amino acid designated as 3,4-dihyd...

Editorial

Cell behaviour in new poly(l-lactic acid) films with crystallinity gradients

We report a new facile method for the development of crystallinity gradients in poly(l-lactic acid) films, based on the gradual dipping of amorphous PLLA samples in a hot bath. Isothermal cold crystallization studies were performed using DSC and optical microscopy in order to find adequate conditions to generate crystallinity gradients in the PLLA films. Cellular response along PLLA samples with graded spheruli...

Effect of freezing on rabbit cultured chondrocytes

This work evaluated the effect of freezing on chondrocytes maintained in culture, aiming the establishment of a cell bank for future application as heterologous implant. Chondrocytes extracted from joint cartilage of nine healthy New Zealand White rabbits were cultivated and frozen with the cryoprotector 5% dimethylsulfoxide for six months. Phenotypic and scanning electron microscopy analyses were carried out t...

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