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Determinação de esforços em tabuleiros de pontes de betão armado construídos tr...

Tese de mestrado integrado. Engenharia Civil (Especialização em Estruturas). Faculdade de Engenharia. Universidade do Porto. 2009

Impaired abstract thinking may discriminate between normal aging and vascular m...

OBJECTIVE: Cerebrovascular disease (CVD) is associated with cognitive deficits. This cross-sectional study examines differences among healthy elderly controls and patients with vascular mild cognitive impairment (VaMCI) and vascular dementia (VaD) in performances on CAMCOG subscales. METHOD: Elderly individuals (n=61) were divided into 3 groups, according to cognitive and neuroimaging status: 16 controls, 20 Va...

Clinical characteristics in subcortical ischemic white matter disease

BACKGROUND: Vascular white matter lesions (WML) represent one of the main neuroimage findings in individuals older than 65 years and its clinical significance is still partially understood. OBJECTIVE: To describe and analyze the clinical profile of a high severity sample with WML focusing on the frontal executive control. METHOD: Outpatients (n=20) with high severity WML evaluated with magnetic resonance imagin...

Binswanger's disease and quantitative fractional anisotropy

OBJECTIVE: To study the integrity of the white matter in Binswanger's disease (BD) patients with quantitative fractional anisotropy (DTI-FA). METHOD: Controls (12) and patients with BD (12) were included. Scans performed with MR (GE Signa Horizon/1.5T). Fazekas's score=6 with white matter hyperintensities extension >75% assessed on FLAIR scans. Standard parameters for DTI-FA were used. ROIs placed in symmetrica...

Intranasal drug delivery: how, why and what for?

Over the recent decades the interest in intranasal delivery as a non-invasive route for drugs is increased. Since the nasal mucosa offers numerous benefits as a target tissue for drug delivery, a wide variety of therapeutic compounds may be administered intranasally for topic, systemic and central nervous system action. We have, herein, outlined the relevant aspects of nasal anatomy, physiology and histology, a...

A produção de manuais didáticos de história do Brasil: remontando ao século XIX...

O artigo decorre de um programa de pesquisa que investiga o papel dos instrumentos do trabalho didático na relação educativa. Elege como foco o discurso dos manuais didáticos de história do Brasil e, para aprofundar a análise do conteúdo, procura apreender as interpretações acerca da Guerra da Tríplice Aliança (1864-1870). Prioriza manuais didáticos pioneiros, produzidos no período imperial, a exemplo de Lições...

Vascular dementia by thalamic strategic infarct

Stereoselective Disposition of S- and R-Licarbazepine in Mice

The stereoselective disposition of S-licarbazepine (S-Lic) and R-licarbazepine (R-Lic) was investigated in plasma, brain, liver, and kidney tissues after their individual administration (350 mg/kg) to mice by oral gavage. Plasma, brain, liver, and kidney concentrations of licarbazepine enantiomers and their metabolites were determined over the time by a validated chiral HPLC-UV method. The mean concentration da...

Stereoselective disposition of S and R-licarbazepine in mice

The stereoselective disposition of S-licarbazepine (S-Lic) and R-licarbazepine (R-Lic) was investigated in plasma, brain, liver, and kidney tissues after their individual administration (350 mg/kg) to mice by oral gavage. Plasma, brain, liver, and kidney concentrations of licarbazepine enantiomers and their metabolites were determined over the time by a validated chiral HPLC-UV method. The mean concentration da...

Caracterização farmacocinética do acetato de eslicarbazepina e dos seus metabol...

O acetato de eslicarbazepina (ESL), designado inicialmente como BIA 2-093, é um novo fármaco que exerce os seus efeitos pelo bloqueio dos canais de sódio dependentes da voltagem, em desenvolvimento clínico para o tratamento da epilepsia, da perturbação bipolar e da dor neuropática. O ESL é um composto química e estruturalmente relacionado com a carbamazepina (CBZ) e a oxcarbazepina (OXC), presentemente em desen...