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Blocking of Pseudomonas aeruginosa biofilm formation by a colistin coating
Alves, Diana Filipa Barros; Lopes, H.; Machado, Idalina; Pereira, M. O.Bacterial colonisation of indwelling devices followed by biofilm formation remains a serious threat in clinical field as it is commonly associated to persistent infections. Once adhered to a surface, bacteria embed themselves in a self-produced matrix mainly composed of extracellular polymeric substances which confers them protection against antimicrobial agents and the host immune system. Early bacterial adhes...
Terpinen-4-ol combined with colistin effectively impairs Pseudomonas aeruginosa...
Coelho, Filipa Alexandra Baltar Lobo; Alves, Diana Filipa Barros; Pereira, M. O.Due to widespread and indiscriminate use of conventional antibiotics, bacteria have acquired a resistant phenotype in response to those antimicrobials pressure. Therefore, microbial infections associated with biofilms have become hard to treat with conventional therapy. The development of microbial drug resistance and drugrelated toxicity has promoted the search for new alternatives, to control, mostly, healthc...
Influence of a quaternary ammonium compound on the cell structure of bacteria u...
Alves, Diana Filipa BarrosDissertação de mestrado integrado em Engenharia Biomédica (área de especialização em Engenharia Clínica) ; Bacterial adhesion and subsequent biofilm formation remains a serious concern, especially in clinical applications, since bacteria associated with biofilms are more resistant to antibiotic treatment and to the host immune system. A potential approach to deal with this drawback may rely on the use of antim...
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