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T cell immunity to mycobacteria : the problem of thymic infection and new + mou...

Tese de doutoramento em Ciências da Saúde ; Despite significant advances in drug discovery and vaccination strategies during the last decades, infectious diseases are still a major health problem worldwide. Among these, infections by mycobacteria are particularly deadly, and Mycobacterium tuberculosis alone – the causative agent of tuberculosis – is estimated to infect a third of the world population and is re...