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T cell immunity to mycobacteria : the problem of thymic infection and new + mou...
Alves, Cláudio António NunesTese de doutoramento em Ciências da Saúde ; Despite significant advances in drug discovery and vaccination strategies during the last decades, infectious diseases are still a major health problem worldwide. Among these, infections by mycobacteria are particularly deadly, and Mycobacterium tuberculosis alone – the causative agent of tuberculosis – is estimated to infect a third of the world population and is re...
T Cells home to the thymus and control infection
Nóbrega, Cláudia; Alves, Cláudio; Rodrigues, Bruno Cerqueira; Roque, Susana; Silva, Palmira Barreira; Behar, Samuel M.; Neves, Margarida CorreiaThe thymus is a target of multiple pathogens. How the immune system responds to thymic infection is largely unknown. Despite being considered an immune-privileged organ, we detect a mycobacteria-specific T cell response in the thymus following dissemination of Mycobacterium avium or Mycobacterium tuberculosis. This response includes proinflammatory cytokine production by mycobacteria-specific CD4(+) and CD8(+) ...
T cells home to the thymus and control infection
Nóbrega, Cláudia; Alves, Cláudio Nunes; Rodrigues, Bruno Miguel Cerqueira; Roque, Susana; Silva, Palmira Barreira da; Behar, Samuel M.The thymus is a target of multiple pathogens. How the immune system responds to thymic infection is largely unknown. Despite being considered an immune-privileged organ, we detect a mycobacteria-specific T cell response in the thymus following dissemination of Mycobacterium avium or Mycobacterium tuberculosis. This response includes proinflammatory cytokine production by mycobacteria-specific CD4(+) and CD8(+) ...
Tolerance has its limits : how the thymus copes with infection
Alves, Cláudio; Nóbrega, Cláudia; Correia-Neves, MargaridaThe thymus is required for T cell differentiation; a process that depends on which antigens are encountered by thymocytes, the environment surrounding the differentiating cells, and the thymic architecture. These features are altered by local infection of the thymus and by the inflammatory mediators that accompany systemic infection. Although once believed to be an immune privileged site, it is now known that a...
Plano de eficiência energética numa unidade industrial
Alves, Cláudio Filipe VieiraTese de mestrado integrado. Engenharia Electrotécnica e de Computadores (Major Energia). Faculdade de Engenharia. Universidade do Porto. 2009
Interplay between depressive-like behavior and the immune system in an animal m...
Roque, Susana; Oliveira, Tiago Gil; Nóbrega, Cláudia; Silva, Palmira Barreira; Alves, Cláudio Nunes; Sousa, Nuno; Palha, Joana AlmeidaGlucocorticoids, namely dexamethasone, are prescribed during late gestation in pregnancies at risk of originating premature newborns, to promote fetal lung maturation. However, adverse early life events have been reported to induce long-lasting changes in the immune and central nervous systems. The accumulating evidence on bidirectional interactions between both systems in psychiatric disorders like depression,...
Mycobacteria-induced anaemia revisited : a molecular approach reveals the invol...
Rodrigues, Pedro; Gomes, Sandro S.; Neves, João V.; Pereira, Sandra Gomes; Neves, Margarida Correia; Alves, Cláudio Nunes; Stolte, Jens; Sanchez, MaykaAnaemia is a frequent complication of chronic infectious diseases but the exact mechanisms by which it develops remain to be clarified. In the present work, we used a mouse model of mycobacterial infection to study molecular alterations of iron metabolism induced by infection. We show that four weeks after infection with Mycobacterium avium BALB/c mice exhibited a moderate anaemia, which was not accompanied by ...
Composição química e valor nutricional para grandes herbívoros das folhas e fru...
Amarante,Cristine Bastos do; Müller,Regina Celi Sarkis; Dantas,Kelly das Graças Fernandes; Alves,Cláudio Nahum; Müller,Adolfo HenriqueMontrichardia linifera (Araceae), conhecida popularmente como 'aninga', faz parte dos ecossistemas de várzea da Amazônia e da dieta natural de animais como peixe-boi, tartarugas, peixes, búfalo e gado. Com o objetivo de contribuir para o conhecimento químico e valor nutricional da mesma, folhas e frutos de M. linifera foram coletados às margens dos rios Guamá e Maratauíra, no Estado do Pará, Brasil. Em folhas e...
Synthesis, X-ray crystal structure and theoretical calculations of antileishman...
Nascimento,Josenaide P. do; Santos,Lourivaldo S.; Santos,Regina Helena A.; Tozzo,Érica; Ferreira,Janaina G.; Carmo,Maria Carolina L. doThe synthesis and X-ray crystal diffraction structure of two analogues of neolignans, 2-(4-chlorophenyl)-1-phenylethanone (20) and 2-[(4-chlorophenyl)thio]-1-(3,4-dimethoxyphenyl)propan-1-one (12) is described. The compound 12 presents activity against intracellular Leishmania donovani and Leishmania amazonensis amastigotes that cause cutaneous and visceral leishmaniasis. In addition, the density functional the...
Isolation, X-ray crystal structure and theoretical calculations of the new comp...
Brasil,Davi S. B.; Müller,Adolfo H.; Guilhon,Gisele M. S. P.; Alves,Cláudio N.; Peris,Gabriel; Llusar,Rosa; Moliner,VicentPhytochemical studies of the bark and leaves of Croton palanostigma Klotzsch (Euphorbiaceae) led to the isolation of a new clerodane diterpene, 8-epicordatin (2), in addition to 12-oxohardwickiic acid methyl ester (3), aparisthman, cordatin (1), ent-trachyloban-18-oic acid, ent-13-epimanoyl oxide, ent-3-oxo-13-epimanoyl oxide, ent-3β-hydroxy-13-epimanoyl oxide, sitosterol, stigmasterol, stigmastan-3-one, 6...
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