Encontrados 4 documentos, a visualizar página 1 de 1
Gradual pore formation in natural origin scaffolds throughout subcutaneous impl...
Martins, Ana M.; Kretlow, J. D.; Pinto, A. R.; Malafaya, P. B.; Fernandes, E. M.; Neves, N. M.; Alves, Catarina M.; Mikos, Antonios G.This study used a rat subcutaneous implantation model to investigate gradual in situ pore formation in a self-regulating degradable chitosan-based material, which comprises lysozyme incorporated into biomimetic calcium phosphate (CaP) coatings at the surface to control the scaffold degradation and subsequent pore formation. Specifically, the in vivo degradation of the scaffolds, the in situ pore formation, and ...
The dynamics, kinetics and reversibility of protein adsorption onto the surface...
Alves, Catarina M.; Reis, R. L.; Hunt, J. A.Dynamic contact angle (DCA) analysis was used to investigate the kinetics and dynamics of protein interactions in a time-dependent manner for a group of organic natural-based surfaces during their initial contact with aqueous and protein solutions. Starch-based biomaterials were used to analyze the influence different materials with different surfaces had on the adsorption, desorption and configuration of prote...
The competitive adsorption of human proteins onto natural-based biomaterials
Alves, Catarina M.; Reis, R. L.; Hunt, John A.This study aims to further the understanding of nanoscale structures relevant for cellular recognition on contact and interaction with natural-based materials. The correlation between surface characteristics and protein adsorption from unitary and complex protein systems was investigated with respect to altering the bulk chemistry of the substrate material. Polymeric blends of starch and cellulose acetate, poly...
The effect of chitosan on the in vitro biological performance of chitosan-poly(...
Coutinho, Daniela F.; Pashkuleva, I.; Alves, Catarina M.; Marques, A. P.; Neves, N. M.; Reis, R. L.Chitosan blends with synthetic biodegradable polymers have been proposed for various biomedical applications due to their versatile mechanical properties and easier processing. However, details regarding the main surface characteristics that may benefit from the blending of these two types of materials are still missing. Hence, this work aims at investigating the surface properties of chitosan-based blends, ill...
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