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TLR9 activation dampens the early inflammatory response to paracoccidioides bra...
Menino, João F.; Saraiva, Margarida; Alves, Ana G. Gomes; Silva, Diogo; Sturme, Mark H. J.; Gomes, Jéssica Angélica Rezende; Pedrosa, JorgeBackground: Paracoccidioides brasiliensis causes paracoccidioidomycosis, one of the most prevalent systemic mycosis in Latin America. Thus, understanding the characteristics of the protective immune response to P. brasiliensis is of interest, as it may reveal targets for disease control. The initiation of the immune response relies on the activation of pattern recognition receptors, among which are TLRs. Both T...
Functionality of the paracoccidioides mating α-pheromone-receptor system
Gomes, Jéssica Angélica Rezende; Alves, Ana G. Gomes; Menino, João F.; Coelho, Marco; Ludovico, Paula; Gonçalves, Paula; Sturme, Mark H. J.Recent evidence suggests that Paracoccidioides species have the potential to undergo sexual reproduction, although no sexual cycle has been identified either in nature or under laboratory conditions. In the present work we detected low expression levels of the heterothallic MAT loci genes MAT1-1 and MAT1-2, the a-pheromone (PBa) gene, and the a- and apheromone receptor (PREB and PREA) genes in yeast and mycelia...
Paracoccidioides brasiliensis : study of the sexual cycle
Alves, Ana G. GomesDissertação de mestrado em Genética Molecular ; The thermodimorphic fungal pathogen Paracoccidioides brasiliensis is the etiological agent of paracoccidioidomycosis, one of the most prevalent systemic mycoses endemic in Latin America, occurring mainly in Brazil, Colombia and Venezuela. The morphological transformation of P. brasiliensis is characterized by the existence of two different morphological forms: a ...
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