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Lipocalin-2 is involved in emotional behaviors and cognitive function
Ferreira, Ana Catarina; Pinto, Vítor; Mesquita, Sandro; Novais, Ashley da Cruz; Sousa, João Carlos; Neves, Margarida Correia; Sousa, NunoLipocalin-2 is involved in emotional behaviors and cognitive function ; Lipocalin-2 (LCN2), an iron-related protein well described to participate in the innate immune response, has been shown to modulate spine morphology and to regulate neuronal excitability. In accordance, LCN2-null mice are reported to have stress-induced anxiety. Here we show that, under standard housing conditions, LCN2-null mice display a...
Modulation of iron metabolism in aging and in Alzheimer's disease: relevance of...
Mesquita, Sandro; Ferreira, A. C.; Sousa, João Carlos; Santos, Nadine Correia; Neves, Margarida Correia; Sousa, Nuno; Palha, Joana AlmeidaIron is essential for mammalian cellular homeostasis. However, in excess, it promotes free radical formation and is associated with aging-related progressive deterioration and with neurodegenerative disorders such as Alzheimer's disease (AD). There are no mechanisms to excrete iron, which makes iron homeostasis a very tightly regulated process at the level of the intestinal absorption. Iron is believed to reach...
Lipocalin 2 is present in the EAE brain and is modulated by natalizumab
Marques, Fernanda; Mesquita, Sandro; Sousa, João; Coppola, Giovanni; Gao, Fuying; Geschwind, Daniel H.; Columba-Cabezas, Sandra; Aloisi, FrancescaThe authors acknowledge the BiogenIdec,for providing Natalizumab (BiogenIdec, Boston,MA,USA).We are thankful to theCOST(EuropeanCooperationinScienceandTechnology) ActionNEURINFNETBM0603.WealsothankDr.NadineSantos for criticallyreviewingthismanuscript. ; Multiple sclerosis (MS) is a demyelinating disease that causes major neurological disability in young adults. A definitive diagnosis at the time of the first e...
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