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Calpains are activated by photodynamic therapy but do not contribute to apoptot...
Almeida, Ramiro D.; Gomes, Edgar R.; Carvalho, Arsélio P.; Duarte, Carlos B.Photodynamic therapy (PDT) of cancer is a promising technique based on the formation of singlet oxygen following irradiation of a sensitizer with visible light. In the present work we investigated the role of calpains in PDT, using the human lymphoblastoid CCRF-CEM cells and bisulfonated aluminum phthalocyanine (AlPcS2) as a sensitizer. Photosensitization induced apoptotic cell death and a time-dependent activa...
Intracellular signaling mechanisms in photodynamic therapy
Almeida, Ramiro D.; Manadas, Bruno J.; Carvalho, Arsélio P.; Duarte, Carlos B.In photodynamic therapy (PDT) a sensitizer, light and oxygen are used to induce death of tumor cells and in the treatment of certain noncancerous conditions. Cell death in PDT may occur by apoptosis or by necrosis, depending on the sensitizer, on the PDT dose and on the cell genotype. Some sensitizers that have been used in PDT are accumulated in the mitochondria, and this may explain their efficiency in induci...
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