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Sustained remission from depressive-like behavior depends on hippocampal neurog...
Pinheiro, António Mateus; Pinto, Luísa; Bessa, J. M.; Morais, Mónica; Alves, N. D.; Monteiro, S.; Patrício, P.; Almeida, O. F. X.; Sousa, NunoWe thank M Carneiro and L Martins for technical assistance. AM-P, LP, MM and SM received fellowships from the Portuguese Foundation for Science and Technology (FCT). This work was supported by FCT (PTDC/SAU-NEU/105180/2008) and the ICVS. ; Impairment of hippocampal neurogenesis has been associated with the expression of depressive-like symptoms and some studies have suggested neurogenesis as a critical factor ...
Mechanisms of initiation and reversal of drug-seeking behavior induced by prena...
Rodrigues, Ana João; Leão, Pedro; Pêgo, José M.; Cardona, Diana; Carvalho, M.; Oliveira, Mário; Costa, Bruno Marques; Carvalho, Ana FrankyWe would like to thank the members of the Neuroscience Research Domain at ICVS for all the helpful discussions and suggestions. We are especially thankful to the animal facility caretakers, and to Drs Sara Silva, António Melo and Ana Paula Silva and Dieter Fischer for their help ; Stress and exposure to glucocorticoids (GC) during early life render individuals vulnerable to brain disorders by inducing structur...
Disconnection and reconnection : the morphological basis of (mal)adaptation to ...
Sousa, Nuno; Almeida, O. F. X.We would like to thank Antonio Pinheiro, Hugo Almeida, and José Miguel Soares for help with the illustrations. We also thank all past and present members of our laboratories for stimulating discussions. ; Maladaptive responses to stress and the associated hypersecretion of glucocorticoids cause psychopathologies ranging from hyperemotional states and mood dysfunction to cognitive impairments. Research in both ...
Potential programming of dopaminergic circuits by early life stress
Rodrigues, Ana João; Leão, Pedro; Carvalho, M.; Almeida, O. F. X.; Sousa, NunoStress and high levels of glucocorticoids during pre- and early postnatal life seem to alter developmental programs that assure dopaminergic transmission in the mesolimbic, mesocortical and nigrostriatal systems. The induced changes are likely to be determined by the ontogenetic state of development of these brain regions at the time of stress exposure and their stability is associated with increased lifetime s...
Citalopram-mediated anxiolysis and differing neurobiological responses in both ...
Kokras, N.; Sotiropoulos, I.; Pitychoutis, P. M.; Almeida, O. F. X.; Papadopoulou-Daifoti, Z.Disorders such as depression and anxiety exhibit strong sex differences in their prevalence and incidence, with women also differing from men in their response to antidepressants. Furthermore, receptors for corticotrophin releasing hormone (CRHR1) and arginine vasopressin receptor subtype 1b (AVPR1b) are known to contribute to the regulation of mood and anxiety. In the present study, we compared the anxiety pro...
Glucocorticoid regulation of astrocytic fate and function
Yu, Shuang; Yang, Silei; Holsboer, F.; Sousa, Nuno; Almeida, O. F. X.Glial loss in the hippocampus has been suggested as a factor in the pathogenesis of stress-related brain disorders that are characterized by dysregulated glucocorticoid (GC) secretion. However, little is known about the regulation of astrocytic fate by GC. Here, we show that astrocytes derived from the rat hippocampus undergo growth inhibition and display moderate activation of caspase 3 after exposure to GC. I...
Stress acts cumulatively to precipitate Alzheimer’s disease-like tau pathology ...
Sotiropoulos, I.; Catania, C.; Pinto, Lucilia G.; Silva, Rui; Pollerberg, G. Elizabeth; Takashima, Akihiko; Sousa, Nuno; Almeida, O. F. X.Stressful life experiences are likely tiological factors in sporadic forms of Alzheimer’s disease (AD). Many AD patients hypersecrete glucocorticoids (GCs), and their GC levels correlate with the rate of cognitive impairment and extent of neuronal atrophy. Severity of cognitive deficits in AD correlates strongly with levels of perphosphorylated forms of the cytoskeletal protein TAU, an essential mediator of the...
Depletion of the neural precursor cell pool by glucocorticoids
Yu, Shuang; Patchev, Alexandre Vladimirov; Wu, Yan; Lu, Jie; Holsboer, F.; Jing-Zhong Zhang; Almeida, O. F. X.OBJECTIVE: Glucocorticoids (GCs) are indicated for a number of conditions in obstetrics and perinatal medicine; however, the neurodevelopmental and long-term neurological consequences of early-life GC exposure are still largely unknown. Preclinical studies have demonstrated that GCs have a major influence on hippocampal cell turnover by inhibiting neurogenesis and stimulating apoptosis of mature neurons. Here w...
A trans-dimensional approach to the behavioral aspects of depression
Bessa, J. M.; Mesquita, Ana Raquel Marcelino; Oliveira, M??rio; P??go, Jos?? M.; Cerqueira, Jo??o; Palha, Joana Almeida; Almeida, O. F. X.; Sousa, NunoDepression, a complex mood disorder, displays high comorbidity with anxiety and cognitive disorders. To establish the extent of inter-dependence between these behavioral domains, we here undertook a systematic analysis to establish interactions between mood [assessed with the forced-swimming (FST) and sucrose consumption tests (SCT)], anxiety [elevated-plus maze (EPM) and novelty suppressed feeding (NSF) tests]...
SMAD pathway mediation of BDNF and TGFβ2 regulation of proliferation and differ...
Lu, J.; Wu, Y.; Sousa, Nuno; Almeida, O. F. X.Hippocampal granule cells self-renew throughout life, whereas their cerebellar counterparts become post-mitotic during early postnatal development, suggesting that locally acting, tissue-specific factors may regulate the proliferative potential of each cell type. Confirming this, we show that conditioned medium from hippocampal cells (CMHippocampus) stimulates proliferation in cerebellar cultures and, vice vers...
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