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PSEUDOXANTHOMA ELASTICUM-LIKE PAPILLARY DERMAL ELASTOLYSIS - A SUBDIAGNOSIS ENT...

Pseudoxanthoma elasticum-like papillary dermal elastolysis (PXE-PDE) is an acquired clinical entity, of unknown etiology, characterized by partial or total absence of elastic fibers in the papillary dermis. We describe the case of a 62-year-old Caucasian woman, Fitzpatrick III skin phototype, with a dermatosis characterized by multiple, asymptomatic, yellowish, monomorphic, rounded papules, with 2-3mm in diamet...

SECONDARY SYPHILIS – CLINICOPATHOLOGICAL CORRELATION

Introduction: In recent years there has been a resurgence of syphilis. Infection by Treponema pallidum is mainly associated with inconsistent condom use and high number of sexual partners in the months preceding the diagnosis. Following the increase number of diagnosed cases, it is important to have a greater awareness of the clinical and pathological features of the disease. This article describes and correlat...

PURPURIC LESIONS OF INFANCY

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RECURRENT NEVUS – A 5-YEAR REVIEW

The development of a melanocytic lesion at the site where it had been previously excised can place clini- cally and histologically some problems because of the differential diagnosis with melanoma, named by some authors as 'pseudomelanoma. In this study, the authors intend to carry out a comparative analysis between the clinical and the pathologic features of recurrent nevi and primary melanocytic lesions.KEYWO...

PROZONE PHENOMENON IN SECONDARY SYPHILIS. THE IMPORTANCE OF COMMUNICATION BETWE...

The prozone phenomenon is defined as a falsely negative test due to very high titters of antibody, as high titters of antigen or antibody may prevent the formation of antigen-antibody complexes in laboratory tests of many diseases, like syphilis or brucellosis. We describe the case of a 27 year old caucasian male admitted in the emergency room with enlarged palpable lymph nodes and a skin eruption either sugges...

BASALIOMA PIGMENTADO DA VULVA – RELEVÂNCIA DO DIAGNÓSTICO DIFERENCIAL COM OUTRA...

Introdução: Os basaliomas são os tumores malignos mais frequentemente encontrados na raça humana e com uma incidência cada vez maior nas últimas décadas. Neste tipo de neoplasias, a vulva é uma localização atípica, provavelmente porque os fatores etiológicos são diferentes dos de outras áreas anatómicas. Têm uma clínica monótona e inespecífica. Caso Clínico: Mulher de 69 anos, que surge com uma placa erosionada...

PATIENT SAFETY IN MELANOMA SURGERY

Introduction: patient safety is a growing concern in healthcare management. The main objectives of our work were the detection of potentially avoidable errors in the treatment of patients with melanoma and search for solutions to improve patient safety. Material and methods: FMEA (Failure Mode and Effect Analysis) was used for analysis of the potentially avoidable errors in melanoma surgery. Results: Failure to...

Tumor-targeted Chlorotoxin-coupled Nanoparticles for Nucleic Acid Delivery to G...

The present work aimed at the development and application of a lipid-based nanocarrier for targeted delivery of nucleic acids to glioblastoma (GBM). For this purpose, chlorotoxin (CTX), a peptide reported to bind selectively to glioma cells while showing no affinity for non-neoplastic cells, was covalently coupled to liposomes encapsulating antisense oligonucleotides (asOs) or small interfering RNAs (siRNAs). T...

New requirements for surgical gowns as protective clothing for the medical staf...

The transference of pathogens through body fluids between surgeon team and patient is a frequent cause of infection. The use of protective surgical apparel is essential to create a barrier to microbial transfer. Surgical gowns are protective clothing with a double effect: protection of the clinical staff and protection of the patient. In the market there are two types of surgical protection materials: disposabl...

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