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Tumor-targeted Chlorotoxin-coupled Nanoparticles for Nucleic Acid Delivery to G...

The present work aimed at the development and application of a lipid-based nanocarrier for targeted delivery of nucleic acids to glioblastoma (GBM). For this purpose, chlorotoxin (CTX), a peptide reported to bind selectively to glioma cells while showing no affinity for non-neoplastic cells, was covalently coupled to liposomes encapsulating antisense oligonucleotides (asOs) or small interfering RNAs (siRNAs). T...

Complete genotyping of mucosal human papillomavirus using a restriction fragmen...

Due to the differences in the oncogenic activity of human papillomaviruses (HPV), it is clinically important to accurately identify HPV types in a simple and time effective manner.Objectives ; http://www.sciencedirect.com/science/article/B6VJV-4S02TKJ-2/1/5a54ef7bf4a02ab8ce983fc89b77b87f

Striatal and nigral pathology in a lentiviral rat model of Machado-Joseph disease

Machado-Joseph disease (MJD) is a fatal, dominant neurodegenerative disorder. MJD results from polyglutamine repeat expansion in the MJD-1 gene, conferring a toxic gain of function to the ataxin-3 protein. In this study, we aimed at overexpressing ataxin-3 in the rat brain using lentiviral vectors (LV), to generate an in vivo MJD genetic model and, to study the disorder in defined brain regions: substantia nigr...

Allele-specific RNA silencing of mutant ataxin-3 mediates neuroprotection in a ...

Recent studies have demonstrated that RNAi is a promising approach for treating autosomal dominant disorders. However, discrimination between wild-type and mutant transcripts is essential, to preserve wild-type expression and function. A single nucleotide polymorphism (SNP) is present in more than 70% of patients with Machado-Joseph disease (MJD). We investigated whether this SNP could be used to inactivate mut...

Modeling dissolution of sparingly soluble multisized powders

The dissolution of powder drugs, besides being a topic of utmost importance, especially for the sparingly soluble ones, is far from being well-explained. The purpose of the present study is, on the one hand, to obtain experimental dissolution profiles and, on the other hand, to analyze and process the data for dissolution modeling. Three different size fractions of a widely used sparingly soluble drug - ibuprof...

Modeling dissolution of sparingly soluble multisized powders

The dissolution of powder drugs, besides being a topic of utmost importance, especially for the sparingly soluble ones, is far from being well-explained. The purpose of the present study is, on the one hand, to obtain experimental dissolution profiles and, on the other hand, to analyze and process the data for dissolution modeling. Three different size fractions of a widely used sparingly soluble drugsibuprofen...

Modelling dissolution of sparingly soluble powders

The present work deals with the simulation of the dissolution process of polydisperse powders. Three different size fractions of Ibuprofen were used to develop a model which assumes a diffusion layer thickness proportional to the particle diameter, up to a critical value, beyond which it is considered constant. The application of the resultant integrated equations to each size class of the primary particle size...

Modelling the dissolution kinetics of ibuprofen