Encontrados 16 documentos, a visualizar página 1 de 2
Resveratrol inhibits the mTOR mitogenic signaling evoked by oxidized LDL in smo...
Brito, Paula M.; Devillard, Raphaël; Nègre-Salvayre, Anne; Almeida, Leonor M.; Dinis, Teresa C. P.; Salvayre, Robert; Augé, Nathaliehttp://www.sciencedirect.com/science/article/B6T12-4V0MTG8-1/2/7b7f3913eea3a6f05047e8c1927696a9
Diphenyl diselenide, a simple glutathione peroxidase mimetic, inhibits human LD...
Bem, Andreza Fabro de; Farina, Marcelo; Portella, Rafael de Lima; Nogueira, Cristina Wayne; Dinis, Teresa C. P.; Laranjinha, João A. N.Oxidative modification of low-density lipoprotein (LDL) represents an important factor in atherogenesis. In the present study, we have investigated the antioxidant capability of diphenyl diselenide (PhSe)2, a simple organoseleno compound, against copper (Cu2+) and peroxyl radical-induced human LDL oxidation in vitro. In initial studies using human serum, (PhSe)2 caused a dose-dependent inhibition of Cu2+-induce...
Resveratrol affords protection against peroxynitrite-mediated endothelial cell ...
Brito, Paula M.; Mariano, Anabela; Almeida, Leonor M.; Dinis, Teresa C. P.Atherosclerosis, the main cause of cardiovascular disease (CD), is a chronic inflammatory condition associated with an overproduction of oxidant species, namely peroxynitrite, which is a powerful oxidant that reacts directly with all biomolecules. Glutathione is an efficient scavenger of peroxynitrite, so, modulation of glutathione synthesis may provide a strategy to selectively protect cells from this oxidant....
Protection of tamoxifen against oxidation of mitochondrial thiols and NAD(P)H u...
Cardoso, Carla M. P.; Almeida, Leonor M.; Custódio, José B. A.The effects of tamoxifen (TAM) were studied on the mitochondrial permeability transition (MPT) induced by the prooxidant tert-butyl hydroperoxide (t-BuOOH) or the thiol cross-linker phenylarsine oxide (PhAsO), in the presence of Ca2+, in order to clarify the mechanisms involved in the MPT inhibition by this drug. The combination of Ca2+ with t-BuOOH or PhAsO induces mitochondrial swelling and depolarization of ...
Comparison of the changes in adenine nucleotides of rat liver mitochondria indu...
Cardoso, Carla M. P.; Moreno, António J. M.; Almeida, Leonor M.; Custódio, José B. A.The antiestrogen tamoxifen (TAM) inhibits the growth of different estrogen receptor (ER)-negative cells. Recently, multiple effects of TAM on mitochondrial bioenergetic functions have been pointed to explain its ER-independent cell death mechanisms. We have shown that TAM and its major active metabolite 4-hydroxytamoxifen (OHTAM) induce depolarization of the mitochondrial membrane potential ([Delta][Psi]) and u...
4-Hydroxytamoxifen induces slight uncoupling of mitochondrial oxidative phospho...
Cardoso, Carla M. P.; Moreno, António J. M.; Almeida, Leonor M.; Custódio, José B. A.The use of tamoxifen (TAM) has been questioned on the chemotherapy and chemoprevention of breast cancer due to several estrogen receptor-independent cytotoxic effects. As an alternative, its more active metabolite 4-hydroxytamoxifen (OHTAM) has been proposed with presumed lower side effects. In this work, the potential OHTAM toxicity on rat liver mitochondrial bioenergetics in relation to the multiple deleterio...
4-Hydroxytamoxifen is a potent inhibitor of the mitochondrial permeability tran...
Cardoso, Carla M. P.; Almeida, Leonor M.; Custódio, José B. A.The effects of 4-hydroxytamoxifen (OHTAM), the major active metabolite of the antiestrogen tamoxifen used in the breast cancer therapy, were studied on the mitochondrial permeability transition (MPT) and bioenergetic functions of mitochondria to evaluate the mechanisms underlying the cell death and toxic effects. The MPT was induced in vitro by incubating rat liver mitochondria with 1 mM inorganic phosphate plu...
Thiol protecting agents and antioxidants inhibit the mitochondrial permeability...
Custódio, José B. A.; Cardoso, Carla M. P.; Almeida, Leonor M.Etoposide (VP-16) is known to promote cell apoptosis either in cancer or in normal cells as a side effect. This fact is preceded by the induction of several mitochondrial events, including increase in Bax/Bcl-2 ratio followed by cytochrome c release and consequent activation of caspase-9 and -3, reduction of ATP levels, depolarization of membrane potential ([Delta][Psi]) and rupture of the outer membrane. These...
Mechanisms of the Deleterious Effects of Tamoxifen on Mitochondrial Respiration...
Cardoso, Carla M. P.; Custódio, José B. A.; Almeida, Leonor M.; Moreno, António J. M.Tamoxifen (TAM), the widely prescribed drug in the prevention and therapy of breast cancer, is a well-known modulator of estrogen receptor (ER) that also inhibits the proliferation of different cell types that lack the ER. However, the ER-independent action mechanisms of TAM and its side effects have not been yet clarified. Mitochondria are essential in supporting the energy-dependent regulation of cell functio...
Inhibition of human LDL lipid peroxidation by phenol-rich beverages and their i...
Serafini, Mauro; Laranjinha, João A. N.; Almeida, Leonor M.; Maiani, G.Mounting evidence shows that phenol-rich beverages exert strong antioxidant activity. However, in vivo evidence has produced conflicting results. In the present study, we studied the impact of the ingestion of 300 mL of black and green tea, alcohol-free red wine, alcohol-free white wine, or water on plasma total antioxidant capacity in five healthy volunteers. Red wine has the highest content of phenolics (3.63...
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