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Práticas de intervenção precoce baseadas nas rotinas: um projecto de formação e...

Resveratrol inhibits the mTOR mitogenic signaling evoked by oxidized LDL in smo...

http://www.sciencedirect.com/science/article/B6T12-4V0MTG8-1/2/7b7f3913eea3a6f05047e8c1927696a9

3,4-Dihydroxyphenylacetic acid (DOPAC) modulates the toxicity induced by nitric...

http://www.sciencedirect.com/science/article/B6W81-4T3DCPW-1/2/1471e87c319c0cc405a12b700ec15c89

Diphenyl diselenide, a simple glutathione peroxidase mimetic, inhibits human LD...

Oxidative modification of low-density lipoprotein (LDL) represents an important factor in atherogenesis. In the present study, we have investigated the antioxidant capability of diphenyl diselenide (PhSe)2, a simple organoseleno compound, against copper (Cu2+) and peroxyl radical-induced human LDL oxidation in vitro. In initial studies using human serum, (PhSe)2 caused a dose-dependent inhibition of Cu2+-induce...

Resveratrol disrupts peroxynitrite-triggered mitochondrial apoptotic pathway: a...

Abstract Resveratrol (3,4',5-trihydroxystilbene) is a phytochemical believed to be partly responsible for the cardioprotective effects of red wine due to its numerous biological activities. Here, we studied biochemical pathways underlying peroxynitrite-mediated apoptosis in endothelial cells and potential mechanisms responsible for resveratrol cytoprotective action. Peroxynitrite triggered endothelial cell apo...

Resveratrol affords protection against peroxynitrite-mediated endothelial cell ...

Atherosclerosis, the main cause of cardiovascular disease (CD), is a chronic inflammatory condition associated with an overproduction of oxidant species, namely peroxynitrite, which is a powerful oxidant that reacts directly with all biomolecules. Glutathione is an efficient scavenger of peroxynitrite, so, modulation of glutathione synthesis may provide a strategy to selectively protect cells from this oxidant....

Life Values Inventory (LVI): Um estudo com mulheres portuguesas

O presente artigo incide sobre a avaliação dos valores, dimensão psicológica central no desenvolvimento da carreira, nomeadamente com a apresentação do Life Values Inventory (LVI), um novo instrumento cuja versão original foi desenvolvida nos USA por Crace e Brown (1996). A adaptação portuguesa do Life Values Inventory (LVI) foi aplicada a um grupo de 209 mulheres de grupos sócio- profissionais diferentes. Apó...

Protection of tamoxifen against oxidation of mitochondrial thiols and NAD(P)H u...

The effects of tamoxifen (TAM) were studied on the mitochondrial permeability transition (MPT) induced by the prooxidant tert-butyl hydroperoxide (t-BuOOH) or the thiol cross-linker phenylarsine oxide (PhAsO), in the presence of Ca2+, in order to clarify the mechanisms involved in the MPT inhibition by this drug. The combination of Ca2+ with t-BuOOH or PhAsO induces mitochondrial swelling and depolarization of ...

Comparison of the changes in adenine nucleotides of rat liver mitochondria indu...

The antiestrogen tamoxifen (TAM) inhibits the growth of different estrogen receptor (ER)-negative cells. Recently, multiple effects of TAM on mitochondrial bioenergetic functions have been pointed to explain its ER-independent cell death mechanisms. We have shown that TAM and its major active metabolite 4-hydroxytamoxifen (OHTAM) induce depolarization of the mitochondrial membrane potential ([Delta][Psi]) and u...

4-Hydroxytamoxifen induces slight uncoupling of mitochondrial oxidative phospho...

The use of tamoxifen (TAM) has been questioned on the chemotherapy and chemoprevention of breast cancer due to several estrogen receptor-independent cytotoxic effects. As an alternative, its more active metabolite 4-hydroxytamoxifen (OHTAM) has been proposed with presumed lower side effects. In this work, the potential OHTAM toxicity on rat liver mitochondrial bioenergetics in relation to the multiple deleterio...