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HIV-2 Integrase Polymorphisms and Longitudinal Genotypic Analysis of HIV-2 Infe...

To characterize the HIV-2 integrase gene polymorphisms and the pathways to resistance of HIV-2 patients failing a raltegravir-containing regimen, we studied 63 integrase strand transfer inhibitors (INSTI)-naïve patients, and 10 heavily pretreated patients exhibiting virological failure while receiving a salvage raltegravir-containing regimen. All patients were infected by HIV-2 group A. 61.4% of the integrase r...

Hiperargininémia. A Propósito de 3 Casos Clínicos

São apresentados 3 casos de hiperargininémia, dois do sexo feminino e um do sexo masculino, com idades compreendidas entre os 5 e os 13 anos. O diagnóstico foi efectuado aos 17, 27 meses e 6 anos de idade, respectivamente, no decurso de um quadro de diplegia espástica progressiva com atraso psicomotor, em dois casos e na ausência de alterações neurológicas no terceiro. Todos eles apresentavam um nível elevado d...

Defeitos da B-Oxidação Mitocondrial: Um Caso Fatal de Deficiência em 3-Hidroxi-...

Descreve-se um caso fatal de deficiência em 3-hidroxi-acil-CoA desidrogenase de cadeia longa (LCHAD) diagnosticado numa criança de 8 meses de idade, segunda filha de um casal jovem, saudável e consanguíneo. Os primeiros sintomas manifestaram-se aos 6,5 meses de idade ao entrar em coma hipoglicémico não cetótico do qual recupera após infusão i.v. de glucose.Detectou-se hepatomegália e posteriormente cardiomegáli...

Raynaud and digital ulcers in patients with juvenile systemic sclerosis: ambula...

Topical caffeine delivery using biocellulose membranes: a potential innovative ...

In this study, biocellulose (BC) membranes have been investigated as caffeine topical delivery systems, for the potential treatment of cellulite. BC-caffeine membranes were prepared by a simple approach and the permeation of caffeine through human epidermis, from BC or from conventional formulation systems (solution and gel), was compared in vitro to assess their therapeutic applicability. Diffusion studies wit...

Vs30 estimation using ambient vibrations and seismic refraction experiments - A...

The town of Lisbon has been affected by several strong earthquakes in the past originated either offshore or inland. The main inland seismogenic zone is the Lower Tagus Valley (LTV) region oriented NNE-SSW and reaching the northern part of Lisbon at its southern end. It is composed by a system of faults mainly oriented according to the valley trend, but the identification of the particular seismogenic structure...

Creative Teaching of New Product Development to Operations Managers

New Product Development (NPD) has got its roots on an Engineering background. Thus, one might wonder about the interest, opportunity, contents and delivery process, if students from soft sciences were involved. This paper addressed «What to teach?» and «How to do it?», as the preliminary research questions that originated the introduced propositions. The curriculum-developer model that was purposefully chosen t...

Vs30 estimation using ambient vibrations and seismic refraction experiments - A...

Effects of emotional valence and three-dimensionality of visual stimuli on brai...

BACKGROUND: Examining changes in brain activation linked with emotion-inducing stimuli is essential to the study of emotions. Due to the ecological potential of techniques such as virtual reality (VR), inspection of whether brain activation in response to emotional stimuli can be modulated by the three-dimensional (3D) properties of the images is important. OBJECTIVE: The current study sought to test whether th...

Feasibility of routine respiratory function testing in preschool children

INTRODUCTION: The assessment of respiratory function in preschool children, which has recently been attracting considerable interest, has several methodological particularities. Whether this is feasible in clinical practice with large groups of patients still needs to be investigated. AIM: To assess the feasibility of pulmonary function testing in preschool children in clinical practice, and report the degree ...