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Driving GDNF expression: The green and the red traffic lights
Saavedra, Ana; Baltazar, Graça; Duarte, Emília P.http://www.sciencedirect.com/science/article/B6T0R-4TCYCK1-4/2/6ab005aaac74c472a6f5d27aaa505084
GDNF modulates HO-1 expression in substantia nigra postnatal cell cultures
Saavedra, Ana; Baltazar, Graça; Carvalho, Caetana M.; Duarte, Emília P.Heme oxygenase-1 (HO-1) has been strongly highlighted because of its induction in many cell types by toxic stimuli, including oxidative stress. The intense HO-1 immunostaining in the substantia nigra of Parkinson disease (PD) patients suggests its involvement in the pathogenesis of this neurodegenerative disease. In this work we investigated HO-1 expression in rat substantia nigra postnatal cell cultures under ...
Differential Expression of Syntaxin 1A and 1B by Noradrenergic and Adrenergic C...
Baltazar, Graça; Carvalho, Arsélio P.; Duarte, Emília P.The expression and localization of syntaxin isoforms 1A and 1B in adrenergic and noradrenergic chromaffin cells were examined by both immunoblot analysis and confocal immunofluorescence microscopy. Syntaxin 1A was found in higher levels in noradrenergic cells, whereas syntaxin 1B was similarly expressed in most noradrenergic and adrenergic cells. However, some heterogeneity was observed within each catecholamin...
Li influx and binding, and li/mg competition in bovine chromaffin cell suspensi...
Fonseca, Carlos P.; Montezinho, Liliana P.; Baltazar, Graça; Layden, Brian; Freitas, Duarte M.; Geraldes, Carlos F. G. C.; Castro, M. Margarida C. A.Li(+) influx by bovine chromaffin cells, obtained from bovine adrenal medulla, was studied in intact cell suspensions using (7)Li NMR spectroscopy with the shift reagent [Tm(HDOTP)](4-). The influx rate constants, k(i), were determined in the absence and in the presence of two Na(+) membrane transport inhibitors. The values obtained indicate that both voltage sensitive Na(+) channels and (Na(+)/K(+))-ATPase pla...
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