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PHD2 regulates arteriogenic macrophages through TIE2 signaling
Hamm, Alexander; Veschini, Lorenzo; Takeda, Yukiji; Costa, Sandra Maria Araújo da; Delamarre, Estelle; Squadrito, Mario Leonardo; Henze, Anne-TheresOcclusion of the main arterial route redirects blood flow to the collateral circulation. We previously reported that macrophages genetically modified to express low levels of prolyl hydroxylase domain protein 2 (PHD2) display an arteriogenic phenotype, which promotes the formation of collateral vessels and protects the skeletal muscle from ischaemic necrosis. However, the molecular mechanisms underlying this pr...
Macrophage skewing by Phd2 haplodeficiency prevents ischemia by inducing arteri...
Takeda, Yukiji; Costa, Sandra Maria Araújo da; Delamarre, Estelle; Roncal, Carmen; Oliveira, Rodrigo Leite de; Squadrito, Mario LeonardoThe authors are thankful to Dr. P. Carmeliet for scientific discussion and support. VE-Cadherin:CreERT and PDGFRB:Cre transgenic mice were generated at the Cancer Research UK (London, UK) and kindly donated by Dr. R. Adams. The IKKβ floxed mice are a generous gift of Dr. M. Karin (UCSD, La Jolla, CA). The hydroxylase-deficient PHD2 construct was given by Dr. P. Ratcliffe (Oxford, UK). ; PHD2 serves as an oxyge...
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