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Co-localization and functional interaction between adenosine A2A and metabotrop...
Rodrigues, Ricardo J.; Alfaro, Tiago M.; Rebola, Nelson; Oliveira, Catarina R.; Cunha, Rodrigo A.The anti-Parkinsonian effect of glutamate metabotropic group 5 (mGluR5) and adenosine A2A receptor antagonists is believed to result from their ability to postsynaptically control the responsiveness of the indirect pathway that is hyperfunctioning in Parkinson's disease. mGluR5 and A2A antagonists are also neuroprotective in brain injury models involving glutamate excitotoxicity. Thus, we hypothesized that the ...
Data: 2005
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Origem: Estudo Geral - Universidade de Coimbra
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