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Unveiling the Interaction of Vanadium Compounds with Human Serum Albumin by Usi...
Dias, David M.; Rodrigues, João P. G. L. M.; Domingues, Neuza S.; Bonvin, Alexandre M. J. J.; Castro, M. M. C. A.The binding of the VV oxidation products of two vanadium( IV) compounds, [VO(dmpp)2] and [VO(maltolato)2], which have shown promising anti-diabetic properties, to human serum albumin (HSA) in aqueous aerobic solution has been studied by 1H saturation transfer difference (STD) NMR spectroscopy and computational docking studies. Group epitope mapping and docking simulations indicate a preference of HSA binding to...
First record of the dusky grouper Epinephelus marginatus (Actinopterygii: Epine...
Condini, Mario V.; Seyboth, Elisa; Vieira, João P.; Varela-Jr., Antônio S.; Barreiros, João P.; Favaro, Luís F.; Garcia, Alexandre M.The dusky grouper Epinephelus marginatus historically exploited by fisheries is a marine species showing slow growth, late maturation and protogynous hermaphroditism. Currently, it is considered as endangered by the IUCN. Therefore, it is essential to increase the knowledge about its biology and ecology to help conservation of this species. The present study reports the first record of a dusky grouper individua...
Sistemas Neuro-Difusos: Técnicas de Modelização Não Linear
José A. B. Vieira; Alexandre M. N. MotaThe artificial intelligence techniques based in fuzzy logic and neural networks are many times applied together. The reasons to combine these two paradigms come out of the difficulties and inherent limitations of each isolated technique. Generically, when they are used in a combined way, they are called Neuro-Fuzzy systems. This term, however, is many times used to assign a specifi...
Design of tch-type sequences for communications
Almeida, Alexandre M. C. Passos deDoctor in Information Science and Technology ; This thesis deals with the design of a class of cyclic codes inspired by TCH codewords. Since TCH codes are linked to finite fields the fundamental concepts and facts about abstract algebra, namely group theory and number theory, constitute the first part of the thesis. By exploring group geometric properties and identifying an equivalence between some operations ...
Folic acid-functionalized human serum albumin nanocapsules for targeted drug de...
Rollett, Alexandra; Reiter, Tamara; Nogueira, Patrícia; Cardinale, Massimiliano; Loureiro, A.; Gomes, Andreia; Paulo, Artur Cavaco; Moreira, AlexandraActivated synovial macrophages play a key role in Rheumatoid Arthritis (RA). Recent studies have shown that folate receptor beta (FRβ) is specifically expressed by activated macrophages. Therefore a folate-based nanodevice would provide the possibility of delivering therapeutic agents to activated macrophages without affecting normal cells and tissues. This study shows for the first time the sonochemical prepa...
Integração em sistemas de informação geográfica da cartografia da SCN 10k como ...
Alexandre, M.J.; Fernandez, P.; Reis, M.J.F.Integração em sistemas de informação geográfica da cartografia da SCN 10k como informação de base para os instrumentos de gestão territorial
Imipramine for vestibular dysfunction in panic disorder: a prospective case series
Mezzasalma,Marco Andre; Mathias,Kátia de Vasconcellos; Nascimento,Isabella; Valença,Alexandre M.; Nardi,Antonio E.OBJECTIVE: The purpose of this study was to evaluate the efficacy and effectiveness of imipramine on the treatment of comorbid chronic dizziness and panic disorder. METHOD: Nine patients with panic disorder and agoraphobia associated with chronic dizziness underwent otoneurological screening and were treated with a 3-months course of imipramine. Anxiety levels were measured with the Hamilton Anxiety Scale (HAM-...
A murine model of xenotransplantation of human glioblastoma with imunosupressio...
Cunha,Alexandre M.; Nascimento,Fernanda S.; Amaral,Jane C.O.F.; Konig,Sandra; Takiya,Crhistina M.; M. Neto,Vivaldo; Rocha,Eduardo; Souza,Jorge P.B.M.Several animal experimental models have been used in the study of malignant gliomas. The objective of the study was to test the efficacy of a simple, reproducible and low cost animal model, using human cells of glioblastoma multiforme (GBM) xenotransplantated in subcutaneous tissue of Wistar rats, immunosuppressed with cyclosporin given by orogastric administration, controlled by nonimunosuppressed rats. The an...
Desenvolvimento e produtividade do maracujazeiro-amarelo irrigado sob diferente...
Carvalho,Jacinto de A.; Koetz,Marcio; Sousa,Alexandre M. G. de; Souza,Kleber J. deA irrigação é uma prática que, além de aumentar a produtividade, pode proporcionar a obtenção de um produto com melhor qualidade. O cultivo do maracujazeiro em ambiente protegido não é uma atividade comum, sendo necessária a pesquisa sob esta condição, especialmente sobre a irrigação. Este trabalho foi conduzido com o objetivo de avaliar o efeito das diferentes tensões de água no solo sobre o comportamento da c...
Checklist comparison and dominance patterns of the fish fauna at Taim Wetland, ...
Garcia, Alexandre M.; Bemvenuti, Marlise de Azevedo; Vieira, João P.; Marques, David Manuel Lelinho da Motta; Burns, Marcelo D.M.; Moresco, AlexO Sistema Hidrológico do Taim é um banhando subtropical localizado no sul do Brasil que abriga uma diversidade biológica excepcional. Em 1978, uma reserva ecológica foi estabelecida para proteger parte dessa área do crescente impacto de ações antrópicas nos seus arredores. Os peixes tem sido muito pouco investigados nessa região. Baseado em coletas com vários amostradores durante vários anos (2001-2005), e em c...
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