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Chronic Obstructive Pulmonary Disease and Proteomics: A Match for Success?

Chronic obstructive pulmonary disease (COPD) is characterized by chronic airflow limitation that is not fully reversible even under bronchodilators effect, caused by a mixture of small airway disease and parenchymal destruction. COPD is a major cause of morbidity and mortality in adults, and it is now the fourth leading death cause in the world. Cigarette smoking is the main risk factor for COPD but not all smo...

Proteomics in Detection and Monitoring Chronic Lung Diseases: The Human Nasal E...

Asthma and chronic obstructive pulmonary disease (COPD) are major causes of mortality and morbidity worldwide. The current state-of-art diagnosis and management schemes are suboptimal for both diseases as the incidence of asthma has risen by 250% over the last two decades and COPD is estimated to become the third leading cause of death worldwide within the next decade. Additionally, these diseases represent a v...

Relatório final de estágio

O presente trabalho visa a elaboração do relatório final de Estágio Pedagógico, sendo realizado como parte integrante e conclusivo do Mestrado em Ensino da Educação Física dos Ensinos Básico e Secundário pela Faculdade de Ciências do Desporto e Educação Física da Universidade de Coimbra. O Estágio Pedagógico foi consumado na Escola Básica 2,3 da Mealhada durante o ano lectivo de 2010/2011, tendo como objectivo ...

Tobacco smoke occupational exposure: biomarkers of biological damage

High concentration of toxic substances emanated from tobacco smoke in entertainment places such as restaurants, bars and nightclubs may compromise indoor air quality (IAQ) generating environments of likelihood health risk. Their employees, particularly those exposed to second-hand smoke, are at increased risk for developing chronic respiratory diseases such as chronic obstructive pulmonary disease (COPD), asthm...

Chronic obstructive pulmonary disease : a proteomics approach

Tese de doutoramento, Biologia (Biologia Molecular), Universidade de Lisboa, Faculdade de Ciências, 2012 ; Chronic obstructive pulmonary disease (COPD) is characterized by chronic airflow limitation that is not fully reversible even under bronchodilators effect, caused by a mixture of small airway disease – obstructive bronchiolitis – and parenchymal destruction – emphysema. At the present time, COPD is the fo...

Proteomic mining of the red blood cell: focus on the membrane proteome

Apolipoproteína E e a doença de Alzheimer

Sabemos hoje que os polimorfismos no gene da apolipoproteína E (apoE) são importantes fatores de risco para o desenvolvimento da doença de Alzheimer (DA). O gene apoE humano, mapeado no braço longo do cromossomo 19 (19q13.2), codifica uma glicoproteína com 317 aminoácidos, a qual desempenha um papel fundamental para o catabolismo de componentes ricos em triglicérides no corpo humano. Em humanos, existem três al...

Surgical management of Guyon's canal syndrome, an ulnar nerve entrapment at the...

Guyon's canal syndrome, an ulnar nerve entrapment at the wrist, is a well-recognized entity. The most common causes that involve the ulnar nerve at the wrist are compression from a ganglion, occupational traumatic neuritis, a musculotendinous arch and disease of the ulnar artery. We describe two cases of Guyon's canal syndrome and discuss the anatomy, aetiology, clinical features, anatomical classification, dia...

Meduloblastoma em adultos: análise de uma casuística e resultados cirúrgicos

Analisamos 15 casos de meduloblastoma em adultos (8 homens e 7 mulheres), com idade média de 23,7 anos (variação de 13 a 46) submetidos a ressecção cirúrgica no período de fevereiro de 1988 a outubro de 1995. Os tumores se localizavam no hemisfério cerebelar em 7 casos (1 com extensão supratentorial e outro atingindo a cisterna do ângulo pontocerebelar), no vermis e hemisférico em 4 e apenas no vermis em outros...