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Strategies for T-cell reconstruction : insights from human clinical models

Tese de doutoramento, Ciências Biomédicas (Ciências Biopatológicas), Universidade de Lisboa, Faculdade de Medicina, 2010 ; The thymus is essential for both the establishment of the peripheral T cell pool and the generation of the diverse T cell receptor (TCR) repertoire capable of dealing with new pathogens and controlling the escape of persistent infections. In humans, the thymus is almost fully developed at ...