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Chitosan and its derivatives as nanocarriers for siRNA delivery
Al-Qadi, Sonia; Grenha, Ana; Remuñán-López, CarmenThe ability to specifically silence genes using siRNA has enormous potential for treating genetic diseases. However, siRNA instability and biodistribution issues still need to be overcome, and adequate delivery vehicles have proven indispensable in conveying siRNA to its target. Chitosan is a promising biopolymer for siRNA delivery, its interest stemming from its safety, biodegradability, mucoadhesivity, permea...
Microspheres loaded with polysaccharide nanoparticles for pulmonary delivery: p...
Al-Qadi, Sonia; Grenha, Ana; Remuñán-López, CarmenIn this work, we report the preparation of a nanoparticle-based dry powder for pulmonary administration. Hybrid chitosan/hyaluronic acid nanoparticles were produced by ionotropic gelation and characterized for their physicochemical properties, being further studied by solid nuclear magnetic resonance (NMR). Using mannitol as carrier, nanoparticles were microencapsulated by spray drying, resulting in a dry powde...
The potential of chitosan for pulmonary drug delivery
Grenha, Ana; Al-Qadi, Sonia; Seijo, Begoña; Remuñán-López, CarmenThe administration of drugs through the pulmonary route offers great advantages, but also requires overcoming many challenges. There is a need to develop appropriate carriers for each active molecule to be delivered to the desired site in the lung, either for a local or a systemic effect. The polysaccharide chitosan is a very promising material for this purpose, given its demonstrated properties of biodegradabi...
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