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FoxP3, GATA-3 and T-bet expression in elderly asthma
Vale-Pereira, S; Todo-Bom, A; Geraldes, L; Schmidt-Weber, C; Akdis, CA; Mota-Pinto, ABACKGROUND: Asthma is a chronic inflammatory disorder in which Th2, Th1 and suppressive T cells (Tregs) play a role. The transcription factor FoxP3 plays a role in Treg differentiation while T-bet is important for Th1 and GATA-3 for Th2 differentiation from naïve T cells. Recent data show that age-related deregulation of Treg cells is a mechanism of senescence affecting several chronic diseases. It is crucial t...
Data: 2011
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Origem: Repositório do Centro Hospitalar e Universitário de Coimbra
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