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An iron-based T1 contrast agent made of iron-phosphate complexes: In vitro and ...
Rodríguez, Elisenda; Simoes, Rui; Roig, Anna; Molins, Elies; Nedelko, Nataliya; Slawska-Waniewska, Anna; Aime, Silvio; Arús, Carles; Cabañas, MiquelAbstract A new iron-based T 1 contrast agent consisting of a complex of iron ions coordinated to phosphate and amine ligands (Fe(phos) in short) has been characterized by spectroscopic and magnetic measurements. NMR relaxation studies showed r 1 values to be dependent on the phosphate salt concentration, K2HPO4, present in the medium. r 1 reaches a maximum value of 2.5 mM-1 s-1 for measurements carried out at ...
Towards Targeted MRI: New MRI Contrast Agents for Sialic Acid Detection
Frullano, Luca; Rohovec, Jan; Aime, Silvio; Maschmeyer, Thomas; Prata, M. Isabel; Lima, J. J. Pedroso de; Geraldes, Carlos F. G. C.; Peters, Joop A.The detection of sialic acid in living systems is of importance for the diagnosis of several types of malignancy. We have designed and synthesized two new lanthanide ion ligands (L1 and L2) that are capable of molecular recognition of sialic acid residues. The basic structure of these ligands consists of a DTPA-bisamide (DTPA, diethylenetriamine pentaacetic acid) whose amide moieties each bear both a boronic fu...
Conformational and Coordination Equilibria on DOTA Complexes of Lanthanide Meta...
Aime, Silvio; Botta, Mauro; Fasano, Mauro; Marques, M. Paula M.; Geraldes, Carlos F. G. C.; Pubanz, Dirk; Merbach, André E.A variable-temperature, -pressure, and -ionic strength 1H NMR study of the DOTA complexes of different trivalent cations (Sc, Y, La, Ce → Lu) (DOTA = 1,4,7,10-tetraaza-1,4,7,10-tetrakis(carboxymethyl)cyclododecane) yielded data that are in contradiction with the hitherto used model of only two enantiomeric pairs of diastereoisomers that differ in the ligand conformations. A two-isomer equilibrium cannot explain...
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