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Biological activity of antitumoural MGBG: the structural variable
Marques, M.; Gil, F.; Calheiros, R.; Battaglia, V.; Brunati, A.; Agostinelli, E.; Toninello, A.Abstract The present study aims at determining the structure-activity relationships (SAR’s) ruling the biological function of MGBG (methylglyoxal bis(guanylhydrazone)), a competitive inhibitor of S-adenosyl-l-methionine decarboxylase displaying anticancer activity, involved in the biosynthesis of the naturally occurring polyamines spermidine and spermine. In order to properly understand its biochemical activit...
Data: 2008
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Origem: Estudo Geral - Universidade de Coimbra
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