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Pulmonary hypertension in Portugal: first data from a nationwide registry
Baptista, A; Meireles, J; Agapito, A; Castro, G; Silva, AM; Shiang, T; Gonçalves, F; Robalo-Martins, S; Nunes-Diogo, A; Reis, AINTRODUCTION: Pulmonary arterial hypertension (PAH) is a rare disease that must be managed in specialized centers; therefore, the availability of epidemiological national data is critical. METHODS: We conducted a prospective, observational, and multicenter registry with a joint collaboration from five centers from Portugal and included adult incident patients with PAH or chronic thromboembolic pulmonary hyperte...
Pulmonary Hypertension in Portugal: First Data from a Nationwide Registry
Baptista, R.; Meireles, J.; Agapito, A.; Castro, G.; Marinho-Silva, A:; Shiang, T.; Gonçalves, F.; Rubalo-Martins, S.; Nunes-Diogo, A.; Reis, A.Introduction. Pulmonary arterial hypertension (PAH) is a rare disease that must be managed in specialized centers; therefore, the availability of epidemiological national data is critical. Methods. We conducted a prospective, observational, and multicenter registry with a joint collaboration from five centers from Portugal and included adult incident patients with PAH or chronic thromboembolic pulmonary hyperte...
Encerramento de Foramen Oval Patente com Dispositivo Bioabsorvível "BioSTAR"
Lopes, JP; Sousa, L; Fiarresga, A; Ferreira, F; Galrinho, A; Martins, JD; Agapito, A; Pinto, MF; Cruz Ferreira, ROs autores apresentam o caso clínico de uma doente de 35 anos, sexo feminino, que recorreu ao hospital da área da residência por parésia do membro superior direito, tendo sido diagnosticado AVC isquémico por Ressonância Magnética Nuclear Cranio-Encefálica (RMN-CE). A investigação da fonte embólica levou ao diagnóstico, por ecocardiograma transesofágico, de foramen oval patente (FOP), com shunt direito-esquerdo ...
Implantação Percutânea de Válvulas Pulmonares: Experiência Inicial
Martins, JD; Ewert, P; Sousa, L; Freitas, I; Trigo, C; Jalles, N; Matos, P; Agapito, A; Cruz Ferreira, R; Pinto, MFOs doentes com cardiopatias submetidos a intervenção cirúrgica com implantação de condutos entre o ventrículo direito e a artéria pulmonar (VD-AP) podem desenvolver estenose e/ou insuficiência pulmonares ao longo do tempo. Nestas situações, associadas a arritmias cardíacas, disfunção ventricular direita e morte súbita, a re-intervenção cirúrgica permanece um desafio pela complexidade, mortalidade e morbilidade ...
Mitral Valve Myxomas: an Unusual Entity
Oliveira, R; Branco, LM; Dias, L; Timóteo, AT; Patrício, L; Agapito, A; Robalo, F; Mendes, J; Pinto, E; Cruz Ferreira, RPrimary tumours of the heart are uncommon entities, cardiac myxomas being the most frequent. However, mitral valve myxomas are exceptionally rare. In the last 12 years, there have been 25 myxomas diagnosed at our institution, with only two of them originating from the mitral valve. Both patients were female, the first, 25, and the second, 72 years old. The younger patient was very symptomatic with a large mass,...
PROP1 gene analysis in Portuguese patients with combined pituitary hormone defi...
Lemos, MC; Gomes, L; Bastos, M; Leite, V; Limbert, E; Carvalho, D; Bacelar, C; Monteiro, M; Fonseca, F; Agapito, A; Castro, JJ; Regateiro, FJOBJECTIVE: Mutations of the PROP1 gene lead to combined pituitary hormone deficiency (CPHD), which is characterized by a deficiency of GH, TSH, LH/FSH, PRL and, less frequently, ACTH. This study was undertaken to investigate the molecular defect in a cohort of patients with CPHD. DESIGN, PATIENTS AND MEASUREMENTS: A multicentric study involving 46 cases of CPHD (17 familial cases belonging to seven kindreds and...
Vasodilatadores Pulmonares Selectivos na Hipertensão Pulmonar Grave: Utilização...
Feliciano, J; Cacela, D; Agapito, A; Sousa, L; Pelicano, NJ; Fiarresga, A; Timóteo, AT; Oliveira, JA; Quininha, JThe therapeutic approach to severe pulmonary arterial hypertension (PAH), whether primary or secondary to connective tissue disorders, thromboembolic phenomena or congenital heart disease with Eisenmenger syndrome, has evolved in recent years following the introduction of selective pulmonary vasodilators, including prostacyclin analogs and endothelin receptor antagonists. AIM: To correlate three different endp...
Tetralogia de Fallot no Adulto
Louro, F; Gomes, A; Almeida, J; Abreu, J; Agapito, A; Magalhães, M; Morgado, AVOs autores apresentam um caso clínico de tetralogia de Fallot num homem de 47 anos, com quadro clínico atípico desde a infância, sujeito a cirurgia correctiva com sucesso. Discutem-se o timing cirúrgico e as complicações pós-operatórias.
Anticorpos Anti-Receptor da TSH na Doença de Graves
Sérgio, M; Godinho, C; Guerra, L; Agapito, A; Fonseca, F; Costa, CNeste trabalho os AA avaliam a sensibilidade, especificidade e valor predictivo do doseamen to dos anticorpos anti-receptor da TSH (TRAb) no diagnóstico da doença de Graves. A população estudada incluiu 80 doentes com doença de Graves recentemente diagnosticada e sem tratamento prévio (grupo 1), 63 doentes com outras patologias tiroideias (grupo II) e 60 indivíduos sem patologia tiroideia (grupo III). Utilizara...
TSH anti-receptor antibodies in Graves' disease.
Sérgio, M R; Laboratório Endocrinologia, Serviço Patologia Clínica, Unidade Endocrinologia do Hospital Curry Cabral, Lisboa.; Godinho, C; Guerra, LThe purpose of this study was to evaluate the sensitivity, specificity and predictive value of thyrotropin receptor antibody (TRAb) in the diagnosis of Graves disease. TRAb was tested by an isotopic receptor assay-TRAK Henning-in 80 newly diagnosed, untreated Graves disease patients (group I), 63 with other thyroid diseases (group II) and 60 controls (group III). In group I, 11 patients were TRAb negative and 7...
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