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Erlotinib in non-small-cell lung cancer patients from Hospital Fernado Fonseca
Fernandes, J; Frade, P; Teixeira, S; Afonso, RINTRODUTION: The oral epidermal growth factor receptor (EGFR) tyrosine-kinase inibitor (TKI) erlotinib is an established second-line treatment for advanced non-small-cell lung cancer (NSCLC).1 Erlotinib delays disease progression and increases survival after first-line chemotherapy in patients with advanced NSCLC as second-line therapy.2 Maintenance therapy with erlotinib, when compared to placebo, could be ass...
Soluble microbial product (SMP) characterization in bench-scale aerobic and ana...
Mesquita,P. L.; Aquino,S. F.; Xavier,A. L. P.; Silva,J. C. Cardoso da; Afonso,R. C. F.; Silva,S. QueirozThis work presents results on the production and characterization (by both mass spectrometry and conventional chemical analyses) of Soluble Microbial Products (SMP) that accumulated in aerobic and anaerobic bench scale completely stirred tank reactors (CSTRs) fed with glucose or acetate under different hydraulic retention times (HRT) and temperatures. SMP accumulation varied from 2 to 68% of the influent COD in...
Correlação de evidências clínicas de inflamação com achados histopatológicos em...
Abreu, Cassiana Burtet; Dornelles, Cristina de Carvalho; Costa, Sady Selaimen da; Meurer, Luíse; Schmidt, Letícia Petersen; Mariante, Afonso R.
Impacto da implementação do impresso de vigilância epidemiológica de prescrição...
Afonso, R; Elias, C; Brito, R; Costa, C; Fernandes, J; Martinho, V; Martins, N; Oliveira, MJ; Prata, P; Teixeira, S; Terrível, R; Almeida, P
Estudo de utilização de albumina humana 20% no Hospital Fernando Fonseca
Afonso, R; Costa, C; Elias, C; Fernandes, J; Ferreira, A; Jesus, S; Oliveira, C; Oliveira, I; Oliveira, MJ; Prata, A; Almeida, P
Efeito do tipo de óleo de soja na composição em ácidos graxos da carcaça de fra...
Martins,R.T.; Cascabulho,A.R.; Baião,N.C.; Afonso,R.J.C.FPara avaliar o efeito de diferentes tipos de óleo de soja na composição em ácidos graxos da carcaça, foram utilizados 128 frangos (64 machos e 64 fêmeas) da linhagem Hubbard. O delineamento experimental foi inteiramente ao acaso, com quatro repetições, e os tratamentos foram constituídos de um fatorial 4 × 2 (quatro dietas e dois sexos). As quatro dietas foram formuladas da seguinte forma: A- sem adição de óleo...
Carbon isotope fluctuations in Precambrian carbonate sequences of several local...
SIAL,ALCIDES N.; FERREIRA,VALDEREZ P.; DEALMEIDA,AFONSO R.; ROMANO,ANTONIO W.; PARENTE,CLOVIS V.; DACOSTA,MARCONDES L.; SANTOS,VICTOR H.Carbon isotope fluctuations in Precambrian sedimentary carbonates between 2.8 Ga and 0.60 Ga in Brazil are examined in this study. The carbonate facies of the BIF of the 2.8 Ga-old Carajás Formation, state of Pará in northern Brazil, has rather homogeneous delta13C (-5 o/ooPDB), compatible with carbonatization of a silicate protolith by a CO2-rich fluid from mantle degassing. The Paleoproterozoic Gandarela Form...
Immunological properties of gene vaccines delivered by different routes
Oliveira,S.C.; Rosinha,G.M.S.; de-Brito,C.F.A.; Fonseca,C.T.; Afonso,R.R.; Costa,M.C.M.S.; Goes,A.M.; Rech,E.L.; Azevedo,V.Gene vaccines represent a new and promising approach to control infectious diseases, inducing a protective immune response in the appropriate host. Several routes and methods of genetic immunization have been shown to induce antibody production as well as T helper (Th) cell and cytotoxic T lymphocyte activation. However, few studies have compared the nature of the immune responses generated by different gene va...
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