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Defining the sister rat mammary tumor cell lines HH-16 cl.2/1 and HH-16.cl.4 as...
Louzada, Sandra; Adega, Filomena; Chaves, RaquelCancer cell lines have been shown to be reliable tools in genetic studies of breast cancer, and the characterization of these lines indicates that they are good models for studying the biological mechanisms underlying this disease. Here, we describe the molecular cytogenetic/genetic characterization of two sister rat mammary tumor cell lines, HH-16 cl.2/1 and HH-16.cl.4, for the first time. Molecular cytogeneti...
Chromosomal evolution in Rattini (Muridae, Rodentia)
Badenhorst, Daleen; Dobigny, Gauthier; Adega, Filomena; Chaves, Raquel; O’Brien, Patricia C. M.; Ferguson-Smith, Malcolm A.; Waters, Paul D.
Anti-hepatocellular carcinoma activity using human HepG2 cells and hepatotoxici...
Abreu, Rui M.V.; Ferreira, Isabel C.F.R.; Calhelha, Ricardo C.; Lima, Raquel T.; Vasconcelos, M. Helena; Adega, Filomena; Chaves, Raquel
Chromosomal instability in a cat mammary cancer cell line
Borges, A.; Adega, Filomena; Escudeiro, A.; Chaves, Raquel
Construction of repetitive DNA libraries from the genomes of two hamster specie...
Paço, Ana; Adega, Filomena; Mestrovic, N.; Silva, A.; Plohl, M.; Chaves, Raquel
Physical location of satellite DNA I family in Peromyscus eremicus (Rodentia, C...
Vieira-da-Silva; Adega, Filomena; Soares, M.; Chaves, Raquel; Guedes-Pinto, Henrique
Anti-hepatocellular carcinoma activity using human HepG2 cells and hepatotoxici...
Abreu, Rui M. V.; Ferreira, Isabel C. F. R.; Calhelha, Ricardo C.; Lima, Raquel T.; Vasconcelos, M. Helena; Adega, Filomena; Chaves, RaquelHepatocellular carcinoma (HCC) is a highly complex cancer, resistant to commonly used treatments and new therapeutic agents are urgently needed. A total of thirty-two thieno[3,2-b]pyridine derivatives of two series: methyl 3-amino-6-(hetero)arylthieno[3,2-b]pyridine-2-carboxylates (1a-1t) and methyl 3-amino-6-[(hetero)arylethynyl]thieno[3,2-b]pyridine-2-carboxylates (2a-2n), previously prepared by some of us, w...
Anti-hepatocellular carcinoma activity using human HepG2 cells and hepatotoxici...
Abreu, Rui M.V.; Ferreira, Isabel C.F.R.; Calhelha, Ricardo C.; Lima, Raquel T.; Vasconcelos, M. Helena; Adega, Filomena; Chaves, RaquelHepatocellular carcinoma (HCC) is a highly complex cancer, resistant to commonly used treatments and new therapeutic agents are urgently needed. A total of thirty-two thieno[3,2-b]pyridine derivatives of two series: methyl 3-amino- -(hetero)arylthieno[3,2-b]pyridine-2-carboxylates (1ae1t) and methyl 3-amino-6-[(hetero)arylethynyl]thieno[3,2-b]pyridine-2-carboxylates (2ae2n), previously prepared by some of us, w...
New potential anti-hepatocellular carcinoma (HCC) agents: in vitro evaluation o...
Abreu, Rui M.V.; Queiroz, Maria João R.P.; Ferreira, Isabel C.F.R.; Calhelha, Ricardo C.; Adega, Filomena; Chaves, RaquelHepatocellular carcinoma (HCC) is a major health problem with more than 660,000 new cases per year worldwide [1]. HCC is resistant to commonly used treatments like chemotherapy and radiotherapy and new anti-HCC therapies are urgently needed. Sorafenib was the first approved small molecule against HCC and underlines the importance of identifying potential new anti-HCC drugs [2]. Thirty-two 6-substituted methyl ...
Candidate genes for cat mammary tumor: a survey from comparative genomic hybrid...
Borges, A.; Chaves, Raquel; Santos, Sara; Gärtner, Fátima; Guedes-Pinto, Henrique; Adega, Filomena
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