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Apresentação do Departamento de Genética Humana do INSA, IP

Também apresentado na Visita de estudo do 11º ano – Curso profissional Escola Amar Terra Verde, Braga, 2014. ; Apresentação da estrutura, organização e atividades do Departamento técnico-científico do INSA,IP, exemplificando o cancro.

Ibuprofen inhibits colitis-induced overexpression of tumor-related Rac1b

The serrated pathway to colorectal tumor formation involves oncogenic mutations in the BRAF gene which are sufficient for initiation of hyperplastic growth but not for tumor progression. The analysis of colorectal tumors revealed that overexpression of splice variant Rac1b occurs in around 80% of tumors with mutant B-Raf and both events were shown to cooperate in tumor cell survival. Here we provide evidence fo...

Doenças genéticas da hipertensão: o papel dos rins na retenção de sais

A novel Rac1/PAK1/BCL-6/STAT5 pathway modulates the expression of cell-cycle-as...

Gene expression depends on binding of transcriptional regulators to gene promoters, a process controlled by signalling pathways. The transcriptional repressor BCL-6 downregulates genes involved in cell cycle progression and becomes inactivated following phosphorylation by the Rac1 GTPase activated protein kinase PAK1. Interestingly, the DNA motifs recognized by BCL-6 and STAT5 are similar. Because STAT5 stimula...

Ibuprofen prevents inflammation-induced increase in Rac1 expression and growth ...

Loss of WNK2 expression by promoter gene methylation occurs in adult gliomas an...

The gene encoding protein kinase WNK2 was recently identified to be silenced by promoter hypermethylation in gliomas and meningiomas, suggesting a tumour-suppressor role in these brain tumours. Following experimental depletion in cell lines, WNK2 was further found to control GTP-loading of Rac1, a signalling guanosine triphosphatase involved in cell migration and motility. Here we show that WNK2 promoter methyl...

Rac1 signalling modulates a STAT5/BCL-6 transcriptional switch on cell cycle-as...

Gene expression depends on binding of transcriptional regulators to gene promoters, a process controlled by signalling pathways. The transcriptional repressor B-cell lymphoma (BCL)-6 downregulates genes involved in cell-cycle progression and becomes inactivated following phosphorylation by the Rac1 GTPase-activated protein kinase PAK1. Interestingly, the DNA motifs recognized by BCL-6 and signal transducers and...

Transcription initiation arising from E-cadherin/CDH1 intron2: a novel protein ...

Disruption of E-cadherin (CDH1 gene) expression, subcellular localization or function arises during initiation and progression of almost 90% of all epithelial carcinomas. Nevertheless, the mechanisms through which this occurs are largely unknown. Previous studies showed the importance of CDH1 intron 2 sequences for proper gene and protein expression, supporting these as E-cadherin cis-modulators. Through RACE a...

Predisposição genética à osteoporose na população Portuguesa causada por varian...

Alternative splicing of tumour-related rac1b is regulated by upstream signallin...

The small GTPase Rac1 regulates signalling pathways controlling actin-dependent cell motility as well as gene transcription. Analternative splicing variant Rac1b is overexpressed in a subset of colorectal tumours and cooperates with mutant B-Raf to sustain tumour cellviability. The alternative splicing mechanism regulating Rac1b expression involves two antagonistic splicing factors, ASF/SF2 and SRp20. Using aRa...