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The HIF1A Functional Genetic Polymorphism at Locus +1772 Associates with Progre...

The hypoxia inducible factor 1 alpha (HIF1a) is a key regulator of tumour cell response to hypoxia, orchestrating mechanisms known to be involved in cancer aggressiveness and metastatic behaviour. In this study we sought to evaluate the association of a functional genetic polymorphism in HIF1A with overall and metastatic prostate cancer (PCa) risk and with response to androgen deprivation therapy (ADT). The HIF...

The HIF1A Functional Genetic Polymorphism at Locus +1772 Associates with Progre...

The hypoxia inducible factor 1 alpha (HIF1a) is a key regulator of tumour cell response to hypoxia, orchestrating mechanisms known to be involved in cancer aggressiveness and metastatic behaviour. In this study we sought to evaluate the association of a functional genetic polymorphism in HIF1A with overall and metastatic prostate cancer (PCa) risk and with response to androgen deprivation therapy (ADT). The HIF...

Impacto da adoção do sistema de normalização contabilística - entidades do seto...

Este estudio tiene como objetivo entender el impacto que la implementación del “Sistema de Normalização Contabilística - Entidades do Setor Não Lucrativo” en los estados financieros de la “Santa Casa daMisericórdia do Porto”, en 2011. En concreto, se pretende evaluar los impactos de la im plementación del“Sistema de Normalização Contabilística - Entidades do Setor Não Lucrativo”, en las diferentes rubricas de l...

Adsorption of n-Pentane on Mesoporous Silica and Adsorbent Deformation

Development of quantitative theory of adsorption-induced deformation is important, e.g., for enhanced coalbed methane recovery by CO2 injection. It is also promising for the interpretation of experimental measurements of elastic properties of porous solids. We study deformation of mesoporous silica by n-pentane adsorption. The shape of experimental strain isotherms for this system differs from the shape predict...

Markers of acute kidney injury: applying theory to practice

Controlo de qualidade: a cereja no topo do bolo

Prémio da Melhor Comunicação Oral ; Introdução: As metodologias de controlo interno de qualidade são uma exigência dos sistemas de certificação e acreditação de laboratórios. A discussão/divulgação deste tipo de ferramentas no contexto da anatomia patológica facilitaria a sua implementação na rotina laboratorial, constituindo um desafio para todos os profissionais. Objectivos: Elaborar uma ferramenta de contr...

Curriculum integration in teacher training: a reflection focused on supervised ...

The Master's degree in Pre-School Education and Teaching in the 1st Cycle of Basic Education, in accordance with the present legislation, includes the component of Supervised Teaching Practice (STP). The way to organize this training component, although regulated by some principles contained in the legal documents, is of the responsibility of each institution of higher education that teaches the course. In this...

Intracardiac Mass Due to Fibrosing Mediastinitis: The First Reported Case

We report a case of a woman, aged 53 years, presenting with a right atrial mass due to idiopathic fibrosing mediastinitis with periaortic involvement. This challenging diagnosis was confirmed by different imaging modalities and histopathologic analysis. The diagnosis of cardiac tumours is often difficult. To our knowledge, this is the first reported case of an intracavitary cardiac mass due to fibrosing mediast...

Numerical approaches in a problem of management of hydroelectric resources

In this paper we consider a simpli ed model for a system of hydro-electric power stations with reversible turbines. The objective of our work is to obtain the optimal pro t of power production satisfying restric- tions on the water level in the reservoirs. Two di erent numerical approaches are applied and compared. These approaches centers on a global optimization technique (Chen-Burer algorithm) and on a Proje...

Band nesting and the optical response of two-dimensional semiconducting transit...

We have studied the optical conductivity of two-dimensional (2D) semiconducting transition metal dichalcogenides using ab initio density functional theory. We find that this class of materials presents large optical response due to the phenomenon of band nesting. The tendency towards band nesting is enhanced by the presence of van Hove singularities in the band structure of these materials. Given that 2D crysta...