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Chemical ecology of echinoderms : impact of environment and diet in metabolomic...
Pereira, David M.; Andrade, Paula B.; Pires, R. A.; Reis, R. L.The phylum Echinodermata constitutes a successful and widespread group comprising Asteroidea, Ophiuroidea, Echinoidea, Holothuroidea and Crinodeia. Nowadays, marine organisms are being given a lot of attention in drug discovery pipelines. In these studies, sponges and nudibranchs are frequently addressed, however an increasing number of works focus their attention in echinoderms. Given the fact that many of the...
Pulmonary hypertension in Portugal: first data from a nationwide registry
Baptista, A; Meireles, J; Agapito, A; Castro, G; Silva, AM; Shiang, T; Gonçalves, F; Robalo-Martins, S; Nunes-Diogo, A; Reis, AINTRODUCTION: Pulmonary arterial hypertension (PAH) is a rare disease that must be managed in specialized centers; therefore, the availability of epidemiological national data is critical. METHODS: We conducted a prospective, observational, and multicenter registry with a joint collaboration from five centers from Portugal and included adult incident patients with PAH or chronic thromboembolic pulmonary hyperte...
Biodiesel from microalgae Chlorella protothecoides growing at autotrophic and h...
Santos, Carla A.; Reis, AlbertoBiodiesel is an alternative energy to fossil fuels, and is produced from biomass, therefore provides lower CO2 emissions. Currently, biodiesel is produced from plant oils, animal fats and used oils. These sources are low-yield which is a limitation to the production of biodiesel in large quantities. On the contrary, microalgae present a very high yield and can be produced in large amounts. The bio-refinery of m...
Development of image analysis methodologies to quantify intracellular PHA, poly...
Amaral, A. L.; Leal, C. S.; Mesquita, D. P.; Cunha, J. R.; Oehmen, A.; Reis, M. A. M.; Ferreira, E. C.In wastewater treatment plants (WWTP), enhanced biological phosphorus removal (EBPR) processes are performed by mixed cultures containing polyphosphate (PAO) and glycogen accumulating organisms (GAO). In these processes, it is of crucial importance to monitor the intracellular metabolism, namely glycogen, polyhydroxyalkanoates (PHA) and polyphosphate (polyP) inclusions, to determine its efficiency. However, tra...
Human adipose stem cells cell sheet constructs impact epidermal morphogenesis i...
Cerqueira, M. T.; Pirraco, R. P.; Santos, T. C.; Rodrigues, D. B.; Frias, A. M.; Martins, A.; Reis, R. L.; Marques, A. P.Among the wide range of strategies to target skin repair/regeneration, tissue engineering (TE) with stem cells at the forefront, remains as the most promising route. Cell sheet (CS) engineering is herein proposed, taking advantage of particular cell-cell and cell-extracellular matrix (ECM) interactions and subsequent cellular milieu, to create 3D TE constructs to promote full-thickness skin wound regeneration. ...
Use of perfusion bioreactors and large animal models for long bone tissue engin...
Gardel, Leandro S.; Serra, L. A.; Reis, R. L.; Gomes, Manuela E.Tissue engineering and regenerative medicine (TERM) strategies for generation of new bone tissue includes the combined use of autologous or heterologous mesenchymal stem cells (MSC) and three-dimensional (3D) scaffold materials serving as structural support for the cells, that develop into tissue-like substitutes under appropriate in vitro culture conditions. This approach is very important due to the limitatio...
Pulmonary Hypertension in Portugal: First Data from a Nationwide Registry
Baptista, R.; Meireles, J.; Agapito, A.; Castro, G.; Marinho-Silva, A:; Shiang, T.; Gonçalves, F.; Rubalo-Martins, S.; Nunes-Diogo, A.; Reis, A.Introduction. Pulmonary arterial hypertension (PAH) is a rare disease that must be managed in specialized centers; therefore, the availability of epidemiological national data is critical. Methods. We conducted a prospective, observational, and multicenter registry with a joint collaboration from five centers from Portugal and included adult incident patients with PAH or chronic thromboembolic pulmonary hyperte...
Identificação de isolados portugueses de Erwinia amylovora
Luz, J.P.; Silva, M.C.A.; Reis, C.M.G.Comunicação oral da qual só está disponível o resumo. ; Identificação de isolados portugueses de Erwinia amylovora.
TWO DECADES OF EARTH SCIENCE RESEARCH
Silva, A.M.; Araújo, A.A.; Reis, A.H.; Morais, M.; Bezzeghoud, M.In 2012, the Évora Geophysics Centre (CGE) celebrates 20 years of activity. In these two decades, the national scientific system underwent a profound transformation, new organizational structures appeared, and participation in structures and international networks, and scientific integration reached very high levels. The national scientific environment is now more qualified and competitive; however the availabl...
Suitability of silk-based 3D biotextiles seeded with human adipose-derived stem...
Ribeiro, V. P.; Martins, A. R.; Marques, A. P.; Bonifácio, G.; Oliveira, A. L.; Sousa, R. A.; Reis, R. L.Human Adipose-derived Stem Cells (hASCs) became an emerging possibility for tissue replacement therapies, such as bone tissue regeneration. Due to their osteogenic differentiation potential, easy isolation, expansion and in vitro proliferation, they have become a highly potential source of seed cells to be seeded in bone tissue engineering (TE) constructs and have demonstrated promising prospects in bone regene...
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