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Ecto-AMP Deaminase Blunts the ATP-Derived Adenosine A2A Receptor Facilitation o...
Magalhães-Cardoso, M. Teresa; Pereira, M. Fátima; Oliveira, Laura; Ribeiro, J. A.; Cunha, Rodrigo A.; Correia-de-Sá, PauloAt synapses, ATP is released and metabolised through ecto-nucleotidases forming adenosine, which modulates neurotransmitter release through inhibitory A1 or facilitatory A2A receptors, according to the amounts of extracellular adenosine. Neuromuscular junctions possess an ecto-AMP deaminase that can dissociate extracellular ATP catabolism from adenosine formation. In this study we have investigated the pattern ...
Enhanced adenosine A2A receptor facilitation of synaptic transmission in the hi...
Rebola, Nelson; Sebastião, Ana M.; Mendonça, Alexandre de; Oliveira, Catarina R.; Ribeiro, J. A.; Cunha, Rodrigo A.Adenosine either inhibits or facilitates synaptic transmission through A1 or A2A receptors, respectively. Since A2A receptor density increases in the limbic cortex of aged (24 mo) compared with young adult rats (2 mo), we tested if A2A receptor modulation of synaptic transmission was also increased in aged rats. The A2A receptor agonist, CGS21680 (10 nM), caused a larger facilitation of the field excitatory pos...
Adenosine A3 receptors in the rat hippocampus: Lack of interaction with A1 rece...
Lopes, Luísa V.; Rebola, Nelson; Costenla, Ana Rita; Halldner, Linda; Jacobson, Marlene A.; Oliveira, Catarina R.; Richardson, Peter J.Adenosine acts as a neuromodulator in the hippocampus essentially through activation of inhibitory A1 receptors. Using single-cell PCR analysis, we found that CA1 pyramidal cells coexpress A1 receptor mRNA together with that of another adenosine receptor, the A3 receptor. As occurs for the A1 receptor, Western blot analysis indicated that the A3 receptor is also located in hippocampal nerve terminals. However, ...
Pertussis toxin prevents presynaptic inhibition by kainate receptors of rat hip...
A. Cunha, Rodrigo; Malva, João O.; Ribeiro, J. A.Kainate receptors are ionotropic receptors, also reported to couple to Gi/Go proteins, increasing neuronal excitability through disinhibition of neuronal circuits. We directly tested in hippocampal synaptosomes if kainate receptor-mediated inhibition of GABA release involved a metabotropic action. The kainate analogue, domoate (3 [mu]M), inhibited by 24% [3H]GABA-evoked release, an effect reduced by 76% in syna...
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