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Insights into the Synthesis of Steroidal A-Ring Olefins
Varela, Carla M.; Roleira, Fernanda M. F.; Costa, Saul C. P.; Tinto, Alexandra S. C. T.; Martins, Ana I. O. S.; Carvalho, Rui A.; Teixeira, Natércia A.one (5), from the D1-3-keto enone, (5a,17b)-3-oxo-5-androst-1-en-17-yl acetate (1), through a strategy involving the reaction of D1-3-hydroxy allylic alcohol, 3b-hydroxy-5a-androst-1-en-17b-yl acetate (2), with SOCl2 , was revisited in order to prepare and biologically evaluate 5 as aromatase inhibitor for breast cancer treatment. Surprisingly, the followed strategy also afforded the isomeric D2-olefin 6 as a b...
Antibioterapia de largo espectro como factor de risco para o isolamento de acin...
Gomes, A; Correia, I; Rocha, R; Sousa, M; Pignatelli, N; Aldomiro, F; Nunes, VAntibioterapia de largo espectro é reconhecida como um factor de risco para a infecções multiresistentes. O objectivo é avaliar a associaçao entre antibioterapia de largo espectro com Meropenem (MP) e Piperacilina/Tazobactam (PT) com o isolamento de Acinetobacter baumanni multiresistente (ABMR). Estudo caso-controlo retrospectivo. Incluidos os individuos com ABMR+ no nosso hospital em 2010. Calculamos a incid...
Remote patient monitoring based on ZigBee : lessons from a real-world deployment
Fernández-López, Helena; Afonso, José A.; Correia, J. H.; Simões, R.This work presents detailed experimental performance results, from tests executed in the hospital environment, for HM4All, a remote vital signs monitoring system based on a ZigBee body sensor network (BSN). Tests involved the use of six electrocardiogram (ECG) sensors operating in two different modes: the ECG mode involved the transmission of ECG waveform data and heart rate (HR) values to the ZigBee coordinato...
Síndrome de Guillain-Barré e Hipertermia Maligna: Uma Nova Associação?
Ferreira, R.; Boto, A.; Correia, M.; Moreno, T; Santos, E.; Oom, P.; Rodrigues, G.A síndrome de Guillain-Barré (SGB) é uma polineuropatia caracterizada por fraqueza muscular progressiva, ascendente e simétrica e arreflexia. O envolvimento de pares cranianos e a disautonomia são frequentes.Os autores descrevem o caso clínico de uma criança de 3 anos com um quadro de arreflexia e fraqueza muscular progressiva, evoluindo em 24 horas para tetraparésia flácida com necessidade de ventilação mecâni...
Effects of helium and deuterium irradiation on SPS sintered W–Ta composites at ...
Mateus, R.; Dias, M.; Lopes, J.; Rocha, J.; Catarino, N.; Franco, N.; Livramento, Vanessa; Carvalho, P. A.; Correia, J. Brito; Hanada, K.; Alves, E.Energetic He+ and D+ ions were implanted into different W–Ta composites in order to investigate their stability under helium and deuterium irradiation. The results were compared with morphological and chemical modifications arising from exposure of pure W and Ta. Special attention was given to tantalum hydride (Ta2H)formation due to its implications for tritium inventory. Three W–Ta composites with 10 and 20 at...
Gravidez na adolescência. Sou mãe. E agora?
Silveira, A; Correia, C; Barrantes, MA realidade no HFF relativamente a gravidezes na adolescência é, segundo dados fornecidos pela Assistente Social do Serviço de Obstetrícia, ainda um número considerável: 135 mães adolescentes em 2007, 72 em 2010, 109 em 2011 e 102 no ano de 2012. O principal objectivo que temos com a apresentação deste trabalho é incutir nos profissionais de saúde que lidam com estas adolescentes diariamente no seu contexto de ...
Synaptic Transmission: Looking for Clues to Autism Spectrum Disorders (ASD) Eti...
Oliveira, B.A.; Correia, C.A.; Conceição, I.C.; Café, C.; Almeida, J.; Mouga, S.; Duque, F.; Oliveira, G.; Vicente, A.M.Copy Number Variants (CNVs) play an important role in susceptibility to ASD, often mediated by the deletion or duplication of genes involved in synaptic structure and function. Increasing evidence suggests a central role for defects in synaptic structure and function in the pathogenesis of non-syndromic ASD. In this study we tested the hypothesis of an enrichment in CNVs encompassing synaptic transmission genes...
Development of nanofiber-reinforced hydrogel scaffolds for nucleus pulposus reg...
Thorvaldsson, A.; Correia, Joana Silva; Oliveira, Joaquim M.; Reis, R. L.; Gatenholm, P.; Walkenström, P.In this work a new method is presented to efficiently produce hydrogel scaffolds reinforced with nanofibers to show enhanced mechanical properties and improved structural integrity. The method is based on a combination of air brush spraying of a hydrogel and electrospinning of nanofibers. With air brush spraying the controllability is enhanced and the potential for scale-up increased. The developed method was u...
Diversity in UV sensitivity and recovery potential among bacterioneuston and ba...
Santos, A. L.; Lopes, S.; Baptista, I.; Henriques, I.; Gomes, N. C. M.; Almeida, A.; Correia, A.; Cunha, A.Aims: To assess the variability in UV-B (280–320 nm) sensitivity of selected bacterial isolates from the surface microlayer and underlying water of the Ria de Aveiro (Portugal) estuary and their ability to recover from previous UVinduced stress. Methods and Results: Bacterial suspensions were exposed to UV-B radiation (3Æ3 W m)2). Effects on culturability and activity were assessed from colony counts and 3H-leu...
A rare cause of pericardial disease
Ramos, V; Vieira, C; Fernandes, N; Nunes-Gonçalves, N; Salgado, A; Correia, AAmong cardiovascular diseases, pericardial disease has specific characteristics. Its etiology, diagnosis and medical management are not as well understood as in coronary and valvular heart disease. In most cases, its cause is benign, although the proportion decreases with more severe clinical presentation. The authors present the case of a 35-year-old man with no relevant past medical history, who went to the e...
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